生醫影像實驗室

主持人

許靖涵博士

現職

聯絡資訊

學經歷

研究興趣

生醫斷層掃描 (PET, SPECT)
生醫影像分析
生醫信號處理
深度/機械學習
數位影像處理
統計信號分析

研究計畫（詳細計畫目錄）

利用深度學習提升低劑量電腦斷層掃描影像品質 

行政服務

資訊電腦網頁委員、 課程委員、 計算機與通訊委員、 共同教育委員、 招生委員、 考試委員。

開授課程（詳細授課目錄）

ORCID:

https://orcid.org/0000-0003-2351-2052

期刊論文

1. Li-Ya Lin, Chih-Chien Nieh, Keng-Li Lan, Ching-Sheng Liu, Ching-Han Hsu, Rong-Jiun Sheu, and Fang-Yuh Hsu, " Microdosimetric characteristics and effective RBE value evaluation of the beam of Taiwan's first heavy ion therapy facility, " Radiation Physics and Chemistry, Vol. 237, pp. 113058, 2025. (doi:10.1016/j.radphyschem.2025.113058)

2. Meng-Che Hsieh, Rou-Zheng Lai, Ching-Han Hsu, Yan-Ren Lin, Pei-You Hsieh, Congo Tak Shing Ching, and Lun-De Liao, " Noncontact monitoring of the peripheral microcirculation using laser speckle contrast imaging to evaluate the skin perfusion pressure, " Results in Engineering, Vol. 26, pp. 105528, 2025. (doi:10.1016/j.rineng.2025.105528)

3. Ying-Ying Tsai, Yu-Jie Chen, Yen-Feng Lin, Fan-Chi Hsiao, Ching-Han Hsu, and Lun-De Liao, " Photoplethysmography-Based HRV Analysis and Machine Learning for Real-Time Stress Quantification in Mental Health Applications, " APL Bioengineering, Vol. 9, No. 2, pp. 026103, 2025. (doi:10.1063/5.0256590)

4. Meng-Che Hsieh, Chia-Yu Chang, Ching-Han Hsu, Congo Tak Shing Ching, and Lun-De Liao, " Comprehensive validation of a compact laser speckle contrast imaging system for vascular function assessment: from the laboratory to the clinic, " Medical & Biological Engineering & Computing , Vol. 63, pp. 641-659, 2025. (doi:10.1007/s11517-024-03211-y)

5. Yi-Ling Fan, Ching-Han Hsu, Ju-Yu Wu, Ying-Ying Tsai, Wei J. Chen, Min-Shi Lee, Fang-Rong Hsu, and Lun-De Liao, " Enhancing Safety with an AI-Empowered Assessment and Monitoring System for BSL-3 Facilities, " Heliyon, Vol. 11, No. 1, pp. e40855, 2025. (doi:10.1016/j.heliyon.2024.e40855)

6. Ju-Yu Wu, Ying-Ying Tsai, Yu-Jie Chen, Fan-Chi Hsiao, Ching-Han Hsu, Yen-Feng Lin, and Lun-De Liao, " Digital transformation of mental health therapy by integrating digitalized cognitive behavioral therapy and eye movement desensitization and reprocessing, " Medical & Biological Engineering & Computing , Vol. 63, pp. 339-354, 2025. (doi:10.1007/s11517-024-03209-6)

7. Chia-Ming Hsieh, Ching-Han Hsu, Jen-Kun Chen, and Lun-De Liao, " AI-Powered Home Cage System for Real-Time Tracking and Analysis of Rodent Behavior, " iScience, Vol. 27, No. 11, pp. 111223, 2024. (doi:10.1016/j.isci.2024.111223)

8. Yi-Ling Fan, Ching-Han Hsu, Fang-Rong Hsu and Lun-De Liao, " Exploring the Use of Deep Learning Models for Accurate Tracking of 3D Zebrafish Trajectories, " Frontiers in Bioengineering and Biotechnology, section Biosensors and Biomolecular Electronics , Vol. 12:1461264, 2024. (doi:10.3389/fbioe.2024.1461264)

9. Hao-Ting Chang, Yu-Chen Chang, Fang-Yuh Hsu, Ching-Han Hsu, " Assessment of fetal dose and occupational exposure for pregnant workers in nuclear medicine using the Taiwanese pregnancy phantom, " Radiation Protection Dosimetry , Vol. 200, No.15, pp 1433–1442, 2024. (doi:10.1093/rpd/ncae181)

10. Meng-Che Hsieh, Chia-Yu Chang, Ching-Han Hsu, Yan-Ren Lin, Pei-You Hsieh, Congo Tak-Shing Ching, Lun-De Liao, " Improvement of clinical wound microcirculation diagnosis using an object tracking-based laser speckle contrast imaging system, " APL Bioeng , 8, 016105, 2024. (doi:10.1063/5.0172443)

11. Chia-Hao Chang, Hsiang-Ning Wu, Ching-Han Hsu, Hsin-Hon Lin, " Virtual monochromatic imaging with projection-based material decomposition algorithm for metal artifacts reduction in photon-counting detector computed tomography, " PLoS ONE , Vol. 18(3), e0282900, 2023. (doi:10.1371/journal.pone.0282900)

12. Hao-Ting Chang, Rui-Wen Liu, Fang-Yuh Hsu, Ching-Han Hsu, Yu-Ying Lin, " Uterine dose conversion coefficients for external photons for the taiwanese pregnant women, " Radiation Protection Dosimetry , Vol. 19(4), pp 325–336, 2023. (doi:10.1093/rpd/ncac283)

13. Chun-Yen Yu, Shih-Wen Wan, Yih-Chyang Weng, Ching-Han Hsu, " Three corrections for overshoot effect improved the dose for step-and-shoot intensity-modulated radiation therapy, " PLoS ONE , Vol. 16(4), e0250243, 2021. (doi:10.1371/journal.pone.0250243)

14. Chia-Chun Lu, Hsin-Hon Lin, Ching-Han Hsu, Fu-Nien Wang, Jao-Perng Lin, Lu-Han Lai, " Potential Use of Environmental Biological Samples for Retrospective Electron Paramagnetic Resonance Dosimetry of Radiation Accidents, " Applied Sciences, Vol. 10, 6867, 2020. (doi:10.3390/app10196867)

15. Chia-Chun Lu, Fu-Nien Wang, Hsin-Hon Lin, Ching-Han Hsu, Jao Perng Lin, Luhan Lai, " Dosimetric Measurement of Testicular Dose for Colorectal Cancer Using Optically-Stimulated Luminescent Dosimeters in Radiotherapy, " Radiation Physics and Chemistry, Vol. 172, pp. 108792, 2020. (doi:10.1016/j.radphyschem.2020.108792)

16. Li-Yen Chen, Yu-Yi Huang, Pei-Ing Lee, Sheng-Chieh Chan, Ku-Hung Lin, Ting-Juan Lin, Yu-Fen Wei, Ching-Han Hsu, Wen-Sheng Huang, Fang-Yuh Hsu, " Radiation safety assessment of caregivers of thyroid cancer patients treated with 131I in Taiwan, " Radiation Physics and Chemistry, Vol. 172, pp. 108781, 2020. (doi:10.1016/j.radphyschem.2020.108781)

17. Shan-Wen Liu, Ching-Han Hsu, Mei-Ru Chen, Ing-Ming Chiu, and Kurt M. Lin, " A Tri-fusion Reporter Mouse Reveals Tissue-Specific FGF1B Promoter Activity in vivo, " Scientific Reports, Vol. 9, pp. 11143, 2019. (doi:10.1038/s41598-019-47641-3)

18. Li-Yen Chen, Ching-Han Hsu, Fang-Yuh Hsu, " Development and efficacy testing of a new optically stimulated luminescence ring dosimeter and algorithm, " Radiation Measurements, Vol. 124, pp. 109 - 115, 2019. (doi:10.1016/j.radmeas.2019.04.006)

19. Yu-Rong Liu, Chia-Yu Huang, Ching-Han Hsu, and Fang-Yuh Hsu, " Dose estimation of eye lens for interventional procedures in diagnosis, " Radiation Physics and Chemistry, Vol. 140, pp. 247 - 251, 2017. (doi:10.1016/j.radphyschem.2017.02.033)

20. Chi-Chang Weng, Siao-Lan Huang, Zi-An Chen, Kun-Ju Lin, Ing-Tsung Hsiao, Tzu-Chen Yen, Mei-Ping Kung, and Shiaw-Pyng Wey, and Ching-Han Hsu, " [18F]FP-(+)-DTBZ PET Study in a Lactacystin-treated Rat Model of Parkinson Disease , " Annals of Nuclear Medicine , Vol. 31, No. 7, pp. 506 - 513, 2017. (doi:10.1007/s12149-017-1174-3 )

21. Chi-Chang Weng, Zi-An Chen, Ko-Ting Chao, Ting-Wei Ee, Kun-Ju Lin, Ming-Huan Chan, Ing-Tsung Hsiao, Tzu-Chen Yen, Mei-Ping Kung, Ching-Han Hsu, and Shiaw-Pyng Wey, " Quantitative analysis of the therapeutic effect of magnolol on MPTP-induced mouse model of Parkinson’s disease using in vivo 18F-9-fluoropropyl-(+)-dihydrotetrabenazine PET imaging, " PLOS ONE , Vol. 12, No. 3, pp. 1 - 13, 2017. (doi:10.1371/journal.pone.0173503 )

22. Tsung-Hsien Chen, Mei-Ru Chen, Tzu-Yin Chen, Tzu-Chin Wu, Shan-Wen Liu, Ching-Han Hsu, Gan-Guang Liou, Yu-Ying Kao, Pao-Hsien Chu, Jiunn-Wang Liao, and Kurt Ming-Chao Lin, " Cardiac Fibrosis Caused by Chronic Insufficiency in Autophagy and Proteasome Degradation in Mouse Expressing DsRed Tetramer, " Oncotarget, Vol. 7, No. 34, pp. 54274 - 54289, 2016. (doi:10.18632/oncotarget.11026)

23. Shi-Wei Lo, Jyh-Horng Wu, Lun-Chi Chen, Chien-Hao Tseng, Fang-Pang Lin, and Ching-Han Hsu, " Uncertainty Comparison of Visual Sensing in Severe Weather Conditions, " Sensors, Vol 16, No. 7, p 1125, 2016. (doi:10.3390/s16071125)

24. Nai-Ming Cheng, Yu-Hua Dean Fang, Din-Li Tsan, Ching-Han Hsu, and Tzu-Chen Yen, " Respiration-averaged CT for attenuation correction of PET images – impact on PET texture features in non-small cell lung cancer patients, " PLOS ONE , Vol. 11, pp. 1 - 15, 2016. (doi:10.1371/journal.pone.0150509)

25. Shi-Wei Lo, Jyh-Horng Wu, Fang-Pang Lin, and Ching-Han Hsu, " Visual Sensing for Urban Flood Monitoring, " Sensors, Vol. 15, pp. 20006 - 20029, 2015. (doi:10.3390/s150820006)

26. Po-Chia Huang and Ching-Han Hsu, " Fast Iterative Reconstruction for Helical Pinhole SPECT Imaging," Bio-Medical Materials and Engineering, Vol. 26, pp. 1371-1380, 2015. (doi:10.3233/BME-151435)

27. Tsung-Hsien Chen, Shan-Wen Liu, Mei-Ru Chen, Kuan-Hung Cho, Tzu-Ying Chen, Pao-Hsien Chu, Yu-Ying Kao, Ching-Han Hsu and Kurt Lin, " Neonatal Death and Heart Failure in Mouse with Transgenic HSP60 Expression, " BioMed Research International , Vol. 2015, pp. 1-11, 2015. (doi:10.1155/2015/539805)

28. Shi-Wei Lo, Jyh-Horng Wu, Fang-Pang Lin, and Ching-Han Hsu, " Cyber Surveillance for Flood Disasters," Sensors, Vol. 15, pp. 2369-2387, 2015. (doi:10.3390/s150202369)

29. Po-Chia Huang, Ho-Hui Hsieh, Ching-Han Hsu, and Ing-Tsung Hsiao " An Efficient Sensitivity Calculation of Tilted Apertures for Preclinical Multipinhole SPECT," Biomedical Engineering-Applications, Basis, and Communications, Vol. 27, pp. 1550006, 2015. (doi:10.4015/S1016237215500064)

30. Nai-Ming Cheng, Yu-Hua Dean Fang, Li-yu Lee, Joseph Tung-Chieh Chang, Din-Li Tsan, Shu-Hang Ng, Hung-Ming Wang, Chun-Ta Liao, Lan-Yan Yang, Ching-Han Hsu, Tzu-Chen Yen, "Zone-size nonuniformity of 18F-FDG PET regional textural features predicts survival in patients with oropharyngeal cancer," European Journal of Nuclear Medicine and Molecular Imaging, Vol.  42, pp. 419-428, 2015. (doi: 10.1007/s00259-014-2933-1)

31. I-Chun Cho, H. Niu, Chien-Hsu Chen, Wen-Tsai Chou, Yueh-Chung Yu, Ching-Han Hsu, "A compact biological cell irradiation system with a Van de Graaff accelerator ," Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol.  315, pp. 360-363, 2013. (doi: 10.1016/j.nimb.2013.03.042)

32. Yung-Chin Hsu, Ching-Han Hsu, Wen-Yih Tseng, "A Large Deformation Diffeomorphic Metric Mapping Solution for Diffusion Spectrum Imaging Datasets," NeuroImage, Vol.  63, pp. 818-834, 2012. (doi: 10.1016/j.neuroimage.2012.07.033)

33. Shan-Wen Liu, Kuan-Hung Cho, Mei-Ru Chen, Hsiao-Chi Yu, Yu-Ying Kao, Tsui-Chun Tsou, Ching-Po Lin, Chin-Tu Chen, Ching-Han Hsu, Kurt Ming-Chao Lin " Ferritin-Red Fluorescent Protein Fusion Reporter for Magnetic Resonance and Optical Imaging," Biomedical Engineering: Applications, Basis, and Communications, Vol.  24, pp. 333 - 341, 2012. (doi: 10.4015/S1016237212500287)

34. Ming-Jay Kuo, Fang-Yuh Hsu, Ching-Han Hsu, Ching-Huang Lo, Tai-Yu Chen, Kuo-Wei Yin, " Evaluation of neutron spectra in the SK cyclotron room under different operation parameters," Radiation Measurements, Vol. 46, pp. 1745-1749, 2011. (doi:10.1016/j.radmeas.2011.04.029)

35. I-Chun Cho, H. Niu, Chien-Hsu Chen, Yueh-Chung Yu, Ching-Han Hsu, " DNA Double-Strand Breaks Induced along the trajectory of particles," Nuclear Instruments and Methods in Physics Research, Section B., Vol. 269, pp. 3129 - 3131, 2011. (doi:10.1016/j.nimb.2011.04.099)

36. I.C. Cho, Jia-Ming Wu, M.F. Weng, S.Y. Chiang, W.T. Chou, H. Niu, Ching-Han Hsu, "A Novel Cell Irradiation System Using 90°-scattering Technique," Nuclear Science, IEEE Trans. on, Vol. 58, pp. 95-98, 2011. (doi:10.1109/TNS.2010.2087036)

37. M.-R. Chen, S.-W. Liu, T.-C. Wu, V. Y. Kao, H.-C. Yu, F. H. Chen,  Ching-Han Hsu, C.-T. Chen, , K. M. Lin, " RU486-inducible recombination in the salivary glands of lactoferrin promoter-driven green fluorescent Cre transgenic mice," Genesis, Vol. 48, pp. 585 - 595, 2010. (doi:10.1002/dvg.20666)

38. Yung-Chin Hsu, Ching-Han Hsu, and Wen-Yih Isaac Tseng, " Evaluation of Diffusion Spectrum Imaging Tractography after Susceptibility-induced Distortion Correction by Model-Based Point Spread Function Method," Chinese Journal of Magnetic Resonance, Vol. 27, pp. 379 - 385, 2010.

39. M.-Y. Chang, Ching-Han Hsu, K M Lin and I-T Hsiao, " An Additive Poisson Data Modeling of Attenuation Map Reconstruction from Post-Injection PET Transmission Scan," Biomedical Engineering-Applications, Basis, and Communications, Vol. 22, pp. 177-184, 2010. (doi:10.4015/S1016237210001918))

40. Ming-Jay Kuo, Fang-Yuh Hsu, Ching-Han Hsu, Ching-Huang Lo, Chien-Ming Chen, Yen-Lin Chang, Jiunn-Hsing Chao and Kuo-Wei Yin, " Dose estimation of the radiation workers in the SK Cyclotron Center using dual-TLD method," Radiation Measurements, Vol. 45, pp. 691-693, 2010. (doi:10.1016/j.radmeas.2009.12.045)

41. S. Rajasekaran, Vivia Y. Kao, Mei-Ru Chen, Alex L. Yang, Ching-Han Hsu, Chin-Tu Chen, Kurt M. Lin, "Detection of Experimentally Induced Pulmonary Granuloma Inflammation in Monocyte Chemoattractant Protein-1 Reporter Mice," Molecular Imaging and Biology, Vol. 12, pp. 163-173, 2010. (doi:10.1007/s11307-009-0261-9)

42. Yung-Chin Hsu, Ching-Han Hsu, Wen-Yih Tseng, "Correction for Susceptibility-induced Distortion in Echo-planar Imaging Using Field Maps and Model-Based Point Spread Function," IEEE Transaction on Medical Imaging, Vol. 28, pp. 1850-1857, 2009. (doi: 10.1109/TMI.2009.2026474)

43. Mei-Ru Chen, Vivia Y. Kao, Shan-Wen Liu, Tzu-Chin Wu, Hsiao-Chi Yu, Ching-Han Hsu, Chin-Tu Chen, Kurt M. Lin, "Non-invasive Optical Imaging for Tracking Gene Delivery and Recombination in Tumor," Biomedical Engineering-Applications, Basis, and Communications, Vol. 21, pp. 355-360, 2009. (doi: 10.4015/S1016237209001441)

44. P-C Huang, Ching-Han Hsu, I-T Hsiao and K M Lin, " An accurate and efficient system model of iterative image reconstruction in high-resolution pinhole SPECT for small animal research," Journal of Instrumentation, Vol. 4, P06007, 2009. (doi: 10.1088/1748-0221/4/06/P06007)

45. C-C Liu, Ching-Han Hsu, I-T Hsiao and K M Lin, " Effect of geometric models on convergence rate in iterative PET image reconstructions," Journal of Instrumentation, Vol. 4, P05010, 2009. (doi: 10.1088/1748-0221/4/05/P05010)

46. Kurt M. Lin, Ching-Han Hsu, Wun-Shaing W. Chang, Chiung-Tong Chen, Te-Wei Lee and Chin-Tu Chen, " Human Breast Tumor Cells Express Multimodal Imaging Reporter Genes," Molecular Imaging and Biology, Vol. 10, No. 5, pp. 1536-1632, 2008. (doi:10.1007/s11307-008-0147-2)

47. Kurt Ming-Chao Lin, Ching-Han Hsu, Subbiah Rajasekaran, " Angiogenic evaluation of ginsenoside Rg1 from Panax ginseng in fluorescent transgenic mice," Vascular Pharmacology, Vol. 49, pp. 37–43, 2008. (doi:10.1016/j.vph.2008.05.002)

48. Ching-Han Hsu and P.C. Huang,  "A geometric system model of finite aperture in small animal pinhole SPECT imaging,"  Computerized Medical Imaging and Graphics, Vol. 30, pp. 181-185, 2006. (doi:10.1016/j.compmedimag.2006.03.004)

49. K. S. Chuang, J Wu, ML Jan, S Chen, and Ching-Han Hsu,  "Novel scatter correction for three-dimensional positron emission tomography by use of a beam stopper device," Nuclear Inst. and Methods in Physics Research, A, Vol. 551, pp. 540-552, 2005. (doi:10.1016/j.nima.2005.06.050)

50. K. S. Chuang, M. L. Jan, J. Wu, S. Chen, Ching-Han Hsu, and Y. K. Fu, "A maximum likelihood expectation maximization algorithm with thresholding ," Computerized Medical Imaging and Graphics, Vol. 29, Issue 7, pp. 571-578, 2005. (doi:10.1016/j.compmedimag.2005.04.003)

51. T.-C. Yen, Y.-C. Chang, S.-C. Chan, Joseph T.-C. Chang, Ching-Han Hsu, K.-J. Lin, W.-J. Lin, Y.-K. Fu and S.-H. Ng, "Are dual-phase 18F-FDG PET scans necessary in nasopharyngeal carcinoma to assess the primary tumour and loco-regional nodes?" European Journal of Nuclear Medicine, Vol. 32, No. 5, pp. 541-548, 2005. (doi:10.1007/s00259-004-1719-2)

52. J. Wu, K. S. Chuang, Ching-Han Hsu, M. L. Jan, I. M. Hwang, and T. J. Chen, "Scatter correction for 3D PET using beam stoppers combined with dual-energy window acquisition: a feasibility study," Physics in Medicine and Biology, Vol. 50 pp. 4593-4607, 2005. (doi:10.1088/0031-9155/50/19/012)

53. P.C. Huang, and Ching-Han Hsu, Ching-Shen Liu, and R.-S. Liu, "A Fully Three-Dimensional Bayesian Image Reconstruction for Small Animal Pinhole SPECT," Biomedical Engineering-Applications, Basis, and Communications, Vol. 16, No. 4, pp 180-184, 2004. (doi:10.4015/S1016237204000244)

54. Ching-Han Hsu, "An Investigation of Block-Sequential Algorithms in Statistical PET Image Reconstruction," Journal of Medical and Biological Engineering, Vol. 24, No. 2, pp. 77-83, 2004.

55. M.-Y. Chang, and Ching-Han Hsu, "An Investigation of Gradient-Based Reconstruction Algorithms for Statistical PET Transmission Imaging," Biomedical Engineering-Applications, Basis, and Communications, Vol. 15, No. 5, pp. 179-185, Oct. 2003. (doi:10.4015/S1016237203000274)

56. Ching-Han Hsu, "A Study of Lesion Contrast Recovery for Iterative PET Image Reconstructions Versus Filtered Backprojection Using an Anthropomorphic Thoracic Phantom," Computerized Medical Imaging and Graphics, Vol. 26, No. 2, pp. 119-127, 2002. (doi:10.1016/S0895-6111(01)00032-5)

57. Ching-Han Hsu, "Statistical positron emission tomography image reconstruction: system geometric models and iterative algorithms," Biomedical Engineering-Applications, Basis, and Communications, Vol. 14, No. 2, pp 47-54, 2002 (doi:10.4015/S1016237202000085).

58. Ching-Han Hsu, "A Bayesian Estimator for PET Imaging Using a Prior Image Model with Mixed Continuity Constraints," Journal of Electronic Imaging, Vol. 9, No. 3, pp. 260-268, 2000. (doi:10.1117/1.482744)

59. Thomas H. Farquhar, Jorge Llacer, Carl K. Hoh, Johannes Czernin, Sanjiv S. Gambhir, Marc A. Seltzer, Daniel H.S. Silverman, Jinyi Qi, Ching-Han Hsu, and Edward J. Hoffman, " ROC and Localization ROC Analyses of Lesion Detection in Whole-Body FDG PET: Effects of Acquisition Mode, Attenuation Correction and Reconstruction Algorithm," Journal of Nuclear Medicine, Vol. 40, No. 12, pp. 2043-2052, 1999.

60. J. Qi, R. Leahy, Ching-Han Hsu, T. Farquhar and S. Cherry, "Fully 3D Bayesian Image Reconstruction for ECAT EXACT HR+," IEEE Transaction on Nuclear Science, Vol. 45, No. 3, pp. 1096-1103, 1998. (doi:10.1109/23.681985)

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