Embryo on LabChip

A genuine increase in infertility has been observed due to various factors including stress, environmental pollution, increasing age, smoking, consumption of alcohol, sexually transmitted dis-eases, etc. In vitro fertilization (IVF), a state-of-the-art technology, increases the rate of pregnancy, offering hope to those with fertility issues. During IVF, fertilized eggs in the blastocyst stage are transferred to the woman’s uterus for implantation and further development. Since the invention of IVF, research advancementshave been made in areas such as chemically and physically improving the culture environment of the pre-implantation embryos and developing specialized culture surfaces.

We develop 3D biomimetic microsystems integrating various functions of the fallopian tube to serve as an in vitro platform for fertilization and embryonic development. These devices mimic the in vivo embryo-endometrial stromal cell monolayer coculture to enhance the group culture of embryos and mechanically culture the embryos in a dynamic manner to enhance their development.






Selected Publication

[1] Kuo-Wei Chang, Pei-Yu Chang, Hong-Yuan Huang,  Chin-Jung Li, Chang-Hung Tien, Da-Jeng Yao, Shih-Kang Fan, Wensyang Hsu and Cheng-Hsien Liu, “Womb-on-a-Chip Biomimetic System for Improved Embryo Culture and Development,” Sensors & Actuators: B. Chemical. Volume 226, Pages 218–226, April 2016.