Principle Investigator

rainban.gif (1969 bytes)

CHI-SHIUN CHIANG, Ph.D.

江啟勳  博士

gr_ball.gif (967 bytes) C.V. gr_ball.gif (967 bytes) Experience gr_ball.gif (967 bytes) Publications

    

 

rainban.gif (1969 bytes)

ADDRESS:

     Department of Biomedical Engineering and Environmental Sciences

    National Tsing Hua University

    101 Sec. 2, Kuang-Fu Road

    Hsinchu 30013

    Taiwan

    (03) 5733168

    (03) 5718649 FAX

    E-mail: cschiang@mx.nthu.edu.tw

 

EDUCATION:

1976-1980        B.Sc. (Biology)

                                 Department of Biology

                                 National Taiwan Normal University, Taiwan

1984-1986        M.S. (Radiation Biology)       

                                  Institute of Radiation Biology       

                                  National Tsing Hwa University, Taiwan

1986-1987        Ph.D. Graduate Student (Biochemistry)

                                  Institute of Biological Chemistry

                                  National Taiwan University, Taiwan

1987-1992        Ph.D. (Biomedical Physics)   

                                 Department of Biomedical Physics

                                 UCLA, U.S.A.

 

AWARD:  

 l     Award for receiving 3 NHRI grants, 2009 (榮獲國家衛生研究院獎助計畫三次獎勵,2009)

l      Research Scholar of Alexander von Humboldt Foundation (Germany), 1999

MEMBERSHIPS

    Radiation Research Society

    American Association for Cancer Research  

Previous ] Home ] Next ]

rainban.gif (1969 bytes)

EXPERIENCE

  

Aug. 2014 -             Chairman

                               Department of Biomedical Engineering and Environmental Sciences

                                National Tsing-Hua University, Taiwan 

Aug. 2009 -             Professor

                                Department of Biomedical Engineering and Environmental Sciences

                                National Tsing-Hua University, Taiwan 

Aug. 1995 - 2009    Associate Professor

                                Department of Biomedical Engineering and Environmental Sciences

                                National Tsing-Hua University, Taiwan

1999-2000               Visiting Scholar

                                Institute for Virology, Jena University, Germany  

1995-Feb.- July       Research Associate

                                Department of Radiation Oncology, UCLA

                                Project title:  "Tumor-directed IL-3 Gene Therapy

Aug. 1993. 1995     Postdoctoral Fellow

                                The Scripps Research Institute

                                Department of Neuropharmacology

                                Project title:  "A transgenic approach to study the neuropathogenesis of cytokines"

1992-Aug. 1993      Postdoctoral Fellow

                                Department of Radiation Oncology, UCLA

                                Project title:  "Tumor-directed Cytokine Gene Therapy

Previous ] Home ] Next ]

rainban.gif (1969 bytes)

PUBLICATIONS

A: Journal article:

1.          Huang, C. Y., Chang, C. W., Chen, C. R., Chuang, C. Y., Chiang, C. S., Shu, W. Y., Fan, T. C., and Hsu, I. C. Extremely low-frequency electromagnetic fields cause G1 phase arrest through the activation of the ATM-Chk2-p21 pathway. PLoS One 9(8): e104732, 2014 (Aug. 11).

2.          Vankayala, R., Chiang, C. S., Chao, J. U., Yuan, C. J., and Lin, S. Y., and Hwang, K.  C. A general strategy to achieve ultra-high gene transfection efficiency using lipid-nanoparticle composites.  Biomaterials. 2014 (June 22, accepted for publication).

3.          Vijayaraghavan, P., Liu, C. H., Vankayala, R., Chiang, C. S. and Hwang, K.  C. Designing multi-branched gold nanoechinus for NIR light activated dual modal photydynamic and phtothermal therapy in the second biological window  Advanced Materials. 2014 (July 3, Published online)

4.          Yu, C. F., Lin, C. M., Wang, S. C., Chen, F. H., Hong, J. H., Tsai, C. S., Yang, Y. C., and *Chiang, C. S. Effects of pre-irradiation and SDF-1 suppression on the progression of murine astrocytoma cells grown in different stromal beds Inter J. Radiat. Biol. 17: 1-18, 2014 (June, Epub ahead of print)

5.          Vankayala, R., Lin, C. C., Kalluru, P., Chiang, C. S. and Hwang, K.  C. Gold nanoshells-mediated biomodal photodynamic and photothermal cancer treatment using ultra-low doses of near infra-red light.  Biomaterials. 35(21): 5527-5538, 2014 (July).

6.          Vankayala, R., Huang, Y. K., Kalluru, P., Chiang, C. S. and Hwang, K.  C. First demonstration of gold nanorods-mediated photodynamic therapeutic destruction of tumors via near infra-red light activation.  Small, 10 (8): 1612 – 1622,  2014 (Apr) 

7.          Vankayala, R., Kalluru, P., Tsai, H. H., Chiang, C. S. and Hwang, K.  C. Effects of surface functionality of carbon nanomaterials on short-term cytotoxicity and embryoic development in zebrafish.  J. Mater. Chem. B. 2(8): 1038-1047, 2014 (Jan).

8.          Kalluru, P., Vankayala, R., Chiang, C. S.‍‍ and Hwang, K. C. Photosensitization of Singlet Oxygen and In vivo Photodynamic Therapeutic Effects Mediated by PEGylated W18O49 Nanowires.  Angew. Chem. Int. Ed.  (ANGEWANDTE CHEMIE-INTERNATIONAL EDITION). 52:12332-12336, 2013 (Nov.).

9.          Vankayala, R., Kuo, C. L., Sagadevan, A., Chen, P. H., Chiang, C. S.‍‍ and Hwang, K. C. Morphology dependent photsensitization and formation of singlet oxygen (1Δg) by gold and silver nanoparticles and its application in cancer treatment. J. Mater. Chem. B. 1 (35): 4379-4387,  2013 (Sep. 21)

10.      Chang, C. W., Chen, C. R., Huang, C. Y., Shu, W. Y., Chiang, C. S., Hong, J. H. and Hsu, I. C. Comparative Transcriptome Profiling of an SV40-Transformed Human Fibroblast (MRC5CVI) and Its Untransformed Counterpart (MRC-5) in Response to UVB Irradiation. PLoS One 8(9): e73311, 2013 (Sep. 11).

11.      Wang, S. C., Yu, C. F., Hong, J. H., Tsai, C. S. and *Chiang, C. S. Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis. PLoS One 8(8): e69182, 2013 (Aug. 5).

12.      Chen, F. H., Fu, S. Y., Yang, Y. C., Wang, C. C., *Chiang, C. S. and *Hong, J. H. Combination of Vessel-Targeting Agents and Fractionated Radiation Therapy: The Role of the SDF-1/CXCR4 Pathway. Int J Radiat Oncol Biol Phys. 86 (4): 777-784, 2013 (June).

13.      Chen, J. J., Fu, S. Y., Chiang, C. S., Hong, J. H. and Yeh, C. K. A preclinical study to explore vasculature differences between primary and recurrent tumors using ultrasound doppler imaging. Ultrasound in Medicine & Biology 39(5):860-869, 2013 (May).

14.      Yu, C. F., Hong, J. H. and *Chiang, C. S. The roles of macrophages and nitric oxide in interleukin-3-enhanced HSV-sr39tk-mediated prodrug therapy. PLoS One 8(2):e56508. , 2013 (Feb. 18).

15.      Chen, J. J., Fu, S. Y., Chiang, C. S., Hong, J. H. and Yeh, J. K. Characterization of tumor vasculature distributions in central and peripheral regions based on Doppler ultrasound. Medical Physics 39(12):7490-7498, 2012 (Dec.).

16.      Wang, T. H., Hsieh, H. A., Hsieh, Y. K., Chiang, C. S, Sun, Y. C. and  Wang, C. F. The in vivo biodistribution and fate of CdSe quantum dots  in the murine model: a laser ablation inductively coupled plasma mass spectrometry study. Anal. Bioanal. Chem. 404 (10): 3025-3036, 2012 (Dec.)

17.      Luo, W.Y., Shih, Y.S., Hung, C.L., Chiang, C. S., Lo, W.H., Huang, S.F., Wang, S.C., Yu, C.F., Chien, C.H. and Hu, Y.C.. Development of the hybrid Sleeping Beauty-baculovirus vector for sustained gene expression and cancer therapy. Gene Therapy 19 (8): 844-851 ,2012 (Aug.)

18.      *Chiang, C.S., Fu, S.Y., Wang, S. C., Yu, C.F., Chen, F.H., Lin, C.M. and Hong, J.H. Irradiation promotes an M2 macrophage phenotype in tumor hypoxia. Front. Oncol.  2: 89-100, 2012 (Aug). (doi: 10.3389/fonc).

19.      Li, C.Y., Chiang, C.S., Cheng, W.C., Wang, S.C., Cheng, H.T., Chen, C.R., Shu, W.Y., Tsai, M.L., Hseu, R.S., Chang, C.W., Huang, C.Y., Fang,.S.H. and Hsu, I.C. Gene Expression Profiling of Dendritic Cells in Different Physiological Stages under Cordyceps sinensis Treatment. PLoS One 7(7):e40824, 2012 (Jul).

20.      Huang, H. L., Chiang, L. W., Chen, J. R., Yang, W. K., Jeng, K. C., Chen, J. T., Duh, T. S., Lin, W. J., Farn, S. S., Chiang, C. S., Huang, C. W.,  Lin, K. I. and Yu, C. S. Study of [18F]FLT and [123I]IaraU for cellular imaging in HSV1 tk-transfected murine fibrosarcoma cells: Evaluation of the tracer uptake using 5-fluoro, 5-iodo and 5-iodovinyl arabinosyl uridines as competitive probes. Nucelar Medicine and Biology 39(3): 371-376, 2012 (April).

21.      Lin, K. J., Wu, C. C., Pan, Y. H., Chen, F. H., Fu, S. Y., Chiang, C. S., Hong, J. H. and Lo, J. M. In vivo imaging of radiation-induced tissue apoptosis by 99mTc(I)-his6-annexin A5. Annals of Nuclear Medicine 26 (3): 272-280, 2012 (April).

22.      Wang, S. C., Hong, J. H., Hsueh, C. and *Chiang, C. S. Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model. Laboratory Investigation 92(1): 151-162, 2012 (Jan).

23.      Huang, C. L., Shu, W. Y., Tsai, M. L., Chiang, C. S., Chang, C. W., Chang, C. T. and Hsu, I. C. Repeated small perturbation approach reveals transcriptomic steady states. PLoS One 6(12): e29241, 2011 (Dec.).

24.      Huang, W. C., Chiang, W. H., Huang, Y. F., Lin, S. C., Shih, Z. F., Chern, C. S., Chiang, C. S. and Chiu, H. C. Nano-scaled pH-responsive polymeric vesicles for intracellular release of doxorubicin. Journal of Drug Targeting  19(10): 944-953, 2011 (Dec.)

25.      Luo, W.Y., Shih, Y.S., Lo, W.H., Chen, H.R., Wang, S.C., Wang, C.H., Chien, C.H., Chiang, C.S., Chuang, Y.J. and Hu, Y.C.. Baculovirus vectors for antiangiogenesis-based cancer gene therapy. Cancer Gene Ther. 18 (9): 637-645, 2011 (Sep.)

26.      Chen, F. H., Chiang, C. S., Wang, C. C., Fu, S. F., Tsai, C. S., Jung, S. M., Wen, C. J. Lee, C. C. and Hong, J. H. Vasculatures in tumors growing from pre-irradiated tissues: formed by vasculogenesis and resistant to radiation and anti-angiogenic therapy. Int. J. Radiation Oncology Biol. Phys. 80 (5):1512 - 1521, 2011 (Aug)

27.      Chen, J. J., Chen, J. J. J., Chiang, C. S., Hong, J. H. and Yeh, J. K. Assessment of tumor vasculature for diagnostic and therapeutic applications in a mouse model in vivo using 25-MHz power Doppler imaging. Ultrasonics   51: 925 – 931, 2011 (May).

28.      Wang, S. C., Wu, C. C., Wei, Y. Y., Hong, J. H. and *Chiang, C. S. Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells. Inter J. Radiat. Biol. 87(4): 432-42, 2011 (Apr)  IF:2.275 (1/35 in NUCLEAR SCIENCE & TECHNOLOGY)

29.  Li, C. Y,.Chao, L. P.,Wang, S. C.,Chang, H. Z., Tsai, M. L., Fang, S. H., Liao, P. C., Ho, C. L., Chen, S. T., Cheng, W. C., Chiang, C. S., Hua, K. F.  and  Hsu, I. C. Honokiol Inhibits LPS-induced Maturation and Inflammatory Response of Human Monocyte-derived Dendritic Cells J. Cellular Physiology  226(9):2338-49, 2011 (Sep.)

 


 

 

30.    Hwang, K. C., Lai, P. D.,Chiang, C. S.,Wang, P. J., Jun-Jye Yuan, J. J. Neutron Capture Nuclei-Containing Carbon Nanoparticles for Destruction of Cancer Cells. Biomaterials 2010, 31(32):8419 -25. IF: 7.36

       http://www.ncbi.nlm.nih.gov/pubmed/20701966

31.    Yang, T.S., Cuin, Y., Wu, C. M., Lo, J. M., Chiang, C. S., Shu, W. Y., Chung, W. J.,  Yu, C. S., Chiang, K. N., and Hsu, I. C. Determining the Zero-Force Binding Energetics of Intercalated DNA Complex Using Single Molecule Approach. ChemPhysChem. 2009, 10(16):2791-2794 (Nov.). IF:3.5 (2/32 in PHYSICS, ATOMIC, MOLECULAR & CHEMICAL

       http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19795434

32.     Li, C. Y., Chiang, C. S., Tsai, M. L., Hseu, R. S., Shu, W. Y., Sun, Y. C., Chang, Y. S., Lin, J. G., Chen, C. S., Chuang, C. Y., and Hsu, I. C. Two-sided effect of Cordyceps sinensis on dendritic cells in different physiological stages. J. Leu. Biol. 2009, 85(6):987-995 (June). IF: 4.128 (25/119 in Imunolog

       http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19261928

33.    Tsai, M. L., Chang, K. Y., Chiang, C. S., Shu, W. Y., Weng, T. C., Chen, C. R., Lin, H. K., Huang, C. L., and Hsu, I. C. UVB induces persistent activation of ribosome and oxidative phosphorylation pathways. Radiat. Res. 2009, 171(6): 716-724 (June)  IF: 2.599 (18/70)

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19580478

34.    Chen, F. H., Chiang, C. S., Wang, C. C., Tsai, C.S., Jung, S. M., Lee, C. C., McBride, W. H., and Hong, J. H. Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumors. Clinic. Cancer Res. 2009, 15 (5):1721 – 1729 (March). IF: 6.250 (15/132)

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19240176

35.     Chang, I. P., Hwang, K. C., and Chiang, C. S. Preparation of Fluorescent Magnetic Nanodiamonds and Cellular Imaging. J. Am. Chem. Soc. 2008, 130(46):15476-15481 (Nov.).  IF: 7.889 (7/127)

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18939829

36.   Liu, W. C., Chuang, W. L., Tsai, M. L., Hong, J. H., McBride, W. H., and Chiang, C. S. Cordyceps sinensis health supplement enhances recovery from taxol-induced leucopenia. Exp. Bio. Med. 2008, 233(4): 447-455 (April). IF:1.979 (37/81 in MEDICINE, RESEARCH & EXPERIMENTAL)

     http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18367634

37.   Chiang, C. S., Chen, F. H., Hong, J. H., Jiang, P.S., Huang, H. L., Wang, C. C., and McBride, W. H. Functional phenotype of macrophages depends on assay procedures. International Immunology 2008 (Feb), 20 (2): 215-222. IF:3.290 (43/119 in Immunology)

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18096562

38.   Chiang, C. S., Yu, C. F., Chiang, L. W., Chen, S. W., Lo, J. M., Yu, C. S. Comparison of bioactivities of 5-fluoro, 5-iodo, 5-iodovinyl, and 5-fluorovinyl arabinosyl uridines against SR-39 TK-transfected murine prostate cancer cells. Chem. Pharm. Bull. 2008 (Jan), 56 (1): 109-111. IF:1.223 (18/41 in CHEMISTRY, MEDICINAL)

       http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18175988

39.   Tsai ,C.S., Chen, F.H., Wang, C.C., Huang, H.L., Jung, S. M., Wu, C. J., Lee, C. C., McBride, H. W., Chiang, C. S., and Hong, J. H. Macrophages from irradiated tumors express higher levels of inos, arginase-I and cox-2, and promote tumor growth. Int. J. Radiation Oncology Biol. Phys. 2007 (June), 68(2):499-507 IF:4.290) (6/87 in RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING)

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17398016

40. Liu, W.C., Wang, S.C., Tsai, M.L., Chen, M.C., Wang, Y.C., Hong, J.H., McBride, W.H., and Chiang, C.S. Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis – a Chinese herbal medicine. Radiation Research. 2006 (Dec.), 166(6):900-907.

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17149981

41. Tsai, C.H., Hong, J.H., Hsieh, K.F., Hsiao, H.W., Chuang, W.L., Lee, C.C., McBride, W.H., and Chiang, C.S. Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer.  Cancer Gene Therapy. 2006 (Dec.), 13 (12):1082-1092

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16841082

42. Chiang, C.S., Liu, W.C., Jung, S.M., Chen, F.H., Wu, C.R., McBride, W.H., Lee, C.C., and Hong, J.H. Compartmental responses after thoracic irradiation of mice: strain differences.  Int. J. Radiation Oncology Biol. Phys. 2005, 62 (3):862–871

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15936571

43. Henke, A., Chiang, C.S, Zell, R., and Stelzner, A. Co-expression of interleukin-2 to increase the efficacy of DNA vaccine-mediated protection in coxsackievirus B3-infected mice. Antiviral Res. 2004 (Nov.), 64(2):131-136

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15498609

44. McBride, W. H., Chiang, C. S., Olson, J. L., Wang, C. C., Hong, J. H., Pajonk, F., Dougherty, G. J., Iwamoto, K. S., Pervan, M. Liao, Y. P. A sense of danger from radiation. Radiat. Res. 2004 (July), 162 (1): 1–19

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15222781

45. Hong, J. H., Jung, S. M. , Tsao, T. C. Y., Wu, C. J., Lee, C. Y., Chen, F. H., Hsu, C. H., McBride, W. H., and Chiang, C. S.  Bronchoalveolar lavage and interstitial cells have different roles in radiation-induced lung injury. Inter. J. Radiat. Biol. 2003 (March), 79 (3): 159-167

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12745880

46. McBride, W. H., Pajonk, F., Chiang, C. S., and Sun, J. R. NF-kappa B, cytokines, proteasomes, and low-dose radiation exposure. Mil. Med. 2002 (Feb.), 167 (2 Supp): 66 – 67

     http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11873521

47. Daigle, J. L., Hong, J. H., Chiang, C. S., and McBride, W. H. The Role of Tumor Necrosis Factor Signaling Pathways in the Response of Murine Brain to Irradiation. Cancer Research, 2001 (Dec.), 61: 8859 – 8865

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11751409

48. Hong, J. H., Chiang, C. S., Tsao, C. Y., Lin, P. Y., Wu. C. R., and McBride, W. H. Can short-term administration of dexamethason abrogate radiation-induced acute cytokine gene response in lung and modify subsequent molecular responses?  Int. J. Radiat. Oncol. Biol. Phys., 2001 (Oct.), 51:296-303

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11567802

49. Wu, Y. Z., Hong, J. H., Huang, H. H., Dougherty, J. G., McBride, W. H., and Chiang, C. S. Mechanisms mediating the effects of IL-3 gene expression on tumor growth.  J. Leukocyte Biology, 2000 (Dec.), 68(6): 890-896

     http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=11129657

50. Chiang, C. S., Hong, J. H., Wu, Y. C., McBride, H. W., and, Dougherty, J. G. Combining radiation therapy with IL-3 gene immunotherapy. Cancer Gene Therapy, 2000 (Aug), 7(8) 1172-1178

      http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10975678

51. Hong, J. H., Chiang, C. S., Tsao, C. Y., Lin, P. Y., McBride, W. H., Wu, C. J. Rapid induction of cytokine gene expression in lung after single and fractionated doses of radiation. International Journal of Radiation Biology, 1999 75:1421-1427 (Nov.)

     http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10597915

52. Powell, H. C., Garrett, R. S., Brett, F. M., Chiang, C. S., Chen, E., Masliah, E., and Campbell, I. L. Response of glia, mast cells and the blood brain barrier, in trasgenic mice expressing interleukin-3 in astrocytes, an experimental model for CNS demyelination.  Brain Pathology 9:219-236, 1999 (Apr.)

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10219739

53. Chiang, C. S., Sawyers, C. L., and McBride, W. H. Oncogene expression and cellular radiation resistance: A modulatory role of c-myc. Molecular Diagnosis 3(1): 21-29, 1998 (March)

     http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10096954

54. Chiang, C. S., Syljuåsen, R. G., Hong, J. H.,Wallis, A., Dougherty, G. J., and McBride, W. H. Effect of IL-3 gene transduction on tumor response to irradiation in vitro and in vivo. Cancer Res. 57(18): 3899-3903, 1997 (Sep.)

      http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9307268

55. Stalder, A. K., Pagenstecher, A., Yu, N. C., Kincaid, C., Chiang, C. S., Hobbs, M. V., Bloom, F. E., and Campbell, I. L. Lipopolysaccharide induced interleukin-12 expression in the CNS and cultured astrocytes and microglia. J. of Immunology 159 (15): 1344-1351 , 1997 (Aug.)

     http://www.ncbi.nlm.nih.gov/cgi-bin/Entrez/referer?http://www.jimmunol.org/cgi-bin/Retreiver.cgi/v159n3/1344/1344-abs-frame.html

56. Chiang, C. S., Hong, J. H., Stalder, A., Sun, J. R., Withers, H. R., and McBride, W. H.. Late-delayed molecular responses to brain irradiation. Inter. J. Radiat. Biol. 72 (1):45-53., 1997 (July)

     http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9246193

57. Campbell, I. L., Stalder, A. K., Chiang, C. S., Steffensen, S., Henriksen, S., Bellinger, B.,Siggins, G.,Heyser, C.,Masliah, E., Powell, H., and Gold, L. H. Transgenic models to assess the pathogenic actions of cytokines in the central nervous system. Mol. Psychiatry 2(2):125-129, 1997 (March).

      http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9106234

58. Hong, J. H., Chiang, C. S., Sun, J. R., Withers, H. R., and McBride, W. H. Induction of c-fos and jun -B mRNA following in vivo brain irradiation. Molecular Brain Research 48 (2): 223-228, 1997

      http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9332719

59. Gold, L. H., Heyser, C.J., Roberts, A.J., Henriksen, S.J., Steffensen, S.C., Siggins, G.R., Bellinger, F.P., Chiang, C. S., Powell, H.C., Masliah, E., et al. Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice. Adv. Exp. Med. Biol., 402:199-205, 1996

     http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8787661

60. McBride, W. H., Economou, J. S., Syljuasen, R., Parrish, C., Hackman, D., Latham, V., Chiang, C. S., and Dougherty, G. J. The effects of cytokine gene tranfer into tumor on host cell infiltration and regression. Anticancer Res. 16: 1139-1144, 1996

      http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8702225

61.Chiang, C. S., Samimi, A., Powell, H. C., Gold, L. and Campbell, I. L. Macrophage/microglia-mediated primary demyelination and motor disease induced by the CNS production of interleukin-3 in transgenic mice. J. Clinc. Invest. 97: 1512 - 1524, 1996 .

     http://www.ncbi.nlm.nih.gov/htbin-post/Omim/getmim%3ffield=medline_uid&search=8617885

62. McBride, W. H., Economou, J. S., Kuber, N., Hong, J. H., Chiang, C. S., Syljuasen, R. G., Dougherty, S. T. and Dougherty, G. J. Modification of tumor microenviroment by cytokine gene transfer. Acta Oncol. 34(3):447-451, 1995

     http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7779438

63. Hong, J. H., Chiang, C. S., Campbell, I. L., Withers, H. R. and McBride, W. H. Induction of acute-phase gene-expression by brain irradiation. Int. J. Radiat. Oncol. Biol. Phys. 33:619-626, 1995

     http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7558951

64. Campbell, I. L. and Chiang, C. S. Cytokine involvement in CNS disease: implications from trangenic mice. Ann. N.Y. Acad. Sci. 771: 310-312, 1995

     http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8597408

65. McBride, W. H., Dougherty, G. D., Wallis, A. E., Economou, J. S., and Chiang, C. S. Interleukin-3 in gene therapy of cancer, Folia Biol.  40: 62-73, 1994.

    http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7958065

66. Hong, J. H., Gatti, R. A., Huo, Y. K., Chiang, C. S., and McBride, W. H. G2/M-phase arrest and release in ataxia telangiectasia and normal cells after exposure to ionizing radiation, Radiat Res.  140: 17-23, 1994.

    http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7938450

67. Chiang, C. S., Stalder, A., Samimi, A., and Campbell, I. L. Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice, Dev Neurosci.  16: 212-21, 1994.

    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7535683

68. Campbell, I. L., Samimi, A., and Chiang, C. S. Expression of the inducible nitric oxide synthase. Correlation with neuropathology and clinical features in mice with lymphocytic choriomeningitis, J Immunol.  153: 3622-9, 1994.

     http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7523499

69. Mason, K. A, Withers, H. R., and Chiang, C. S. Late effects of radiation on the lumbar spinal cord of guinea pigs: re-treatment tolerance, Int J Radiat Oncol Biol Phys. 26(4):643-648, 1993

     http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8330995

70. Chiang, C. S., McBride, W. H., and Withers, H. R. Myelin-associated changes in mouse brain following irradiation, Radiother Oncol.  27: 229-36, 1993

     http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7692473

71. Chiang, C. S., McBride, W. H., and Withers, H. R. Radiation-induced astrocytic and microglial responses in mouse brain, Radiother Oncol.  29: 60-8, 1993.

     http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8295989

72. Chiang, C. S., Mason, K. A., Withers, H. R., and McBride, W. H. Alteration in myelin-associated proteins following spinal cord irradiation in guinea pigs [see comments], Int J Radiat Oncol Biol Phys.  24: 929-37, 1992.

    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1280252

73. Chiang, C. S. and McBride, W. H. Radiation enhances tumor necrosis factor alpha production by murine brain cells, Brain Res.  566: 265-9, 1991.

   http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=1814542

 

B. Book Section:

1.      McBride, W. H., Dougherty, G. J., Syljuasen, R., Chiang, C. S., and Daigle, J. L. New molecular and genetic approaches aimed at improving radiation therapy.  In Progress in Radio-Oncology Vol. VI, Kogelnik, H. D., and Seldmayer, F. eds. Monduzi Editore S.p. A. – Bologna (Italy), pp. 27-33, 1998

2.      McBride, W. H., Chiang, C. S., Hong, J. H., and Withers, H. R. Molecular and celluar responses of the brain to radiotherapy. In Progress in Anti-Cancer Chemotherapy, Vol. 1 Khayat, D. and Hortobagyi, G. N. eds. Blackwell Science Ltd. MA, Chap. 6, pp.91 – 132, 1997

3.      Gold, L. H., Heyser, C. H., Roberts, A. J., Henriksen, S. J., Steffensen, S. C., Siggins, G. R., Bellinger, F. P., Chiang, C. S., Powell, H. C., Masliah, E., and Campbell, I. L. Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice.  In AIDS, Drugs of Abuse, and the Neuroimmune Axis, Friedmann et all eds.  Plenum Press, New York, Chap. 26. pp. 199 – 205, 1996

4.      Chiang, C. S., Dougherty, G. J., Economou, J. S. and McBride, W. H. Tumor-directd cytokine gene therapy. In Gene therapy - from laboratory to the clinic, K. M. Hui, eds. World Scientific Publishing Co. Pte. Ltd., New Jersey, pp. 20-44. 1994

5.      McBride, W. H. and Chiang, C. S. The response of normal brain tissue to irradiation. In Stereotatctic surgery and radiosurgery, A. A. F. De Salles and S. J. Goetsch, eds. Medical Physics Publishing, Wisconsin, pp. 159-167. 1993

 

 


Previous Home Next