Principle Investigator
CHI-SHIUN CHIANG, Ph.D.
江啟勳 博士
Department of Biomedical Engineering and Environmental Sciences
National Tsing Hua University
101 Sec. 2, Kuang-Fu Road
Hsinchu 30013
Taiwan
(03) 5733168
(03) 5718649 FAX
E-mail: cschiang@mx.nthu.edu.tw
EDUCATION:
1976-1980
B.Sc. (Biology)
Department of Biology
National Taiwan Normal University, Taiwan
1984-1986 M.S. (Radiation Biology)
Institute of Radiation Biology
National Tsing Hwa University, Taiwan
1986-1987 Ph.D. Graduate Student
(Biochemistry)
Institute of Biological Chemistry
National Taiwan University, Taiwan
1987-1992 Ph.D. (Biomedical Physics)
Department of Biomedical Physics
UCLA, U.S.A.
AWARD:
l Award for receiving 3 NHRI grants, 2009 （榮獲國家衛生研究院獎助計畫三次獎勵,2009)
l Research Scholar of Alexander von Humboldt Foundation (Germany), 1999
MEMBERSHIPS
Radiation Research Society
American Association for Cancer Research
Aug. 2014 - Chairman
Department of
National Tsing-Hua University, Taiwan
Aug. 2009 - Professor
Department of
National Tsing-Hua University, Taiwan
Aug. 1995 -
2009 Associate
Professor
Department of
National Tsing-Hua University, Taiwan
1999-2000 Visiting Scholar
Institute for Virology,
Jena University, Germany
1995-Feb.-
July Research Associate
Department of Radiation Oncology, UCLA
Project title: "Tumor-directed
IL-3 Gene Therapy
Aug.
1993. 1995 Postdoctoral Fellow
The Scripps Research
Institute
Department of
Neuropharmacology
Project title: "A
transgenic approach to study the neuropathogenesis of cytokines"
1992-Aug.
1993 Postdoctoral Fellow
Department of Radiation
Oncology, UCLA
Project title:
"Tumor-directed Cytokine Gene Therapy
A: Journal article:
1. Huang, C. Y., Chang, C. W., Chen, C. R., Chuang, C. Y., Chiang, C. S., Shu, W. Y., Fan, T. C., and Hsu, I. C. Extremely low-frequency electromagnetic fields cause G1 phase arrest through the activation of the ATM-Chk2-p21 pathway. PLoS One 9(8): e104732, 2014 (Aug. 11).
2. Vankayala, R., Chiang, C. S., Chao, J. U., Yuan, C. J., and Lin, S. Y., and Hwang, K. C. A general strategy to achieve ultra-high gene transfection efficiency using lipid-nanoparticle composites. Biomaterials. 2014 (June 22, accepted for publication).
3. Vijayaraghavan, P., Liu, C. H., Vankayala, R., Chiang, C. S. and Hwang, K. C. Designing multi-branched gold nanoechinus for NIR light activated dual modal photydynamic and phtothermal therapy in the second biological window Advanced Materials. 2014 (July 3, Published online)
4. Yu, C. F., Lin, C. M., Wang, S. C., Chen, F. H., Hong, J. H., Tsai, C. S., Yang, Y. C., and *Chiang, C. S. Effects of pre-irradiation and SDF-1 suppression on the progression of murine astrocytoma cells grown in different stromal beds Inter J. Radiat. Biol. 17: 1-18, 2014 (June, Epub ahead of print)
5. Vankayala, R., Lin, C. C., Kalluru, P., Chiang, C. S. and Hwang, K. C. Gold nanoshells-mediated biomodal photodynamic and photothermal cancer treatment using ultra-low doses of near infra-red light. Biomaterials. 35(21): 5527-5538, 2014 (July).
6. Vankayala, R., Huang, Y. K., Kalluru, P., Chiang, C. S. and Hwang, K. C. First demonstration of gold nanorods-mediated photodynamic therapeutic destruction of tumors via near infra-red light activation. Small, 10 (8): 1612 – 1622, 2014 (Apr)
7. Vankayala, R., Kalluru, P., Tsai, H. H., Chiang, C. S. and Hwang, K. C. Effects of surface functionality of carbon nanomaterials on short-term cytotoxicity and embryoic development in zebrafish. J. Mater. Chem. B. 2(8): 1038-1047, 2014 (Jan).
8. Kalluru, P., Vankayala, R., Chiang, C. S. and Hwang, K. C. Photosensitization of Singlet Oxygen and In vivo Photodynamic Therapeutic Effects Mediated by PEGylated W18O49 Nanowires. Angew. Chem. Int. Ed. (ANGEWANDTE CHEMIE-INTERNATIONAL EDITION). 52:12332-12336, 2013 (Nov.).
9. Vankayala, R., Kuo, C. L., Sagadevan, A., Chen, P. H., Chiang, C. S. and Hwang, K. C. Morphology dependent photsensitization and formation of singlet oxygen (1Δg) by gold and silver nanoparticles and its application in cancer treatment. J. Mater. Chem. B. 1 (35): 4379-4387, 2013 (Sep. 21)
10. Chang, C. W., Chen, C. R., Huang, C. Y., Shu, W. Y., Chiang, C. S., Hong, J. H. and Hsu, I. C. Comparative Transcriptome Profiling of an SV40-Transformed Human Fibroblast (MRC5CVI) and Its Untransformed Counterpart (MRC-5) in Response to UVB Irradiation. PLoS One 8(9): e73311, 2013 (Sep. 11).
11. Wang, S. C., Yu, C. F., Hong, J. H., Tsai, C. S. and *Chiang, C. S. Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis. PLoS One 8(8): e69182, 2013 (Aug. 5).
12. Chen, F. H., Fu, S. Y., Yang, Y. C., Wang, C. C., *Chiang, C. S. and *Hong, J. H. Combination of Vessel-Targeting Agents and Fractionated Radiation Therapy: The Role of the SDF-1/CXCR4 Pathway. Int J Radiat Oncol Biol Phys. 86 (4): 777-784, 2013 (June).
13. Chen, J. J., Fu, S. Y., Chiang, C. S., Hong, J. H. and Yeh, C. K. A preclinical study to explore vasculature differences between primary and recurrent tumors using ultrasound doppler imaging. Ultrasound in Medicine & Biology 39(5):860-869, 2013 (May).
14. Yu, C. F., Hong, J. H. and *Chiang, C. S. The roles of macrophages and nitric oxide in interleukin-3-enhanced HSV-sr39tk-mediated prodrug therapy. PLoS One 8(2):e56508. , 2013 (Feb. 18).
15. Chen, J. J., Fu, S. Y., Chiang, C. S., Hong, J. H. and Yeh, J. K. Characterization of tumor vasculature distributions in central and peripheral regions based on Doppler ultrasound. Medical Physics 39(12):7490-7498, 2012 (Dec.).
16. Wang, T. H., Hsieh, H. A., Hsieh, Y. K., Chiang, C. S, Sun, Y. C. and Wang, C. F. The in vivo biodistribution and fate of CdSe quantum dots in the murine model: a laser ablation inductively coupled plasma mass spectrometry study. Anal. Bioanal. Chem. 404 (10): 3025-3036, 2012 (Dec.)
17. Luo, W.Y., Shih, Y.S., Hung, C.L., Chiang, C. S., Lo, W.H., Huang, S.F., Wang, S.C., Yu, C.F., Chien, C.H. and Hu, Y.C.. Development of the hybrid Sleeping Beauty-baculovirus vector for sustained gene expression and cancer therapy. Gene Therapy 19 (8): 844-851 ,2012 (Aug.)
18.
*Chiang,
C.S.,
Fu, S.Y., Wang, S. C., Yu, C.F., Chen, F.H., Lin, C.M. and Hong, J.H.
Irradiation promotes an M2 macrophage phenotype in tumor hypoxia. Front.
Oncol. 2:
89-100, 2012 (Aug). (doi:
10.3389/fonc).
19. Li, C.Y., Chiang, C.S., Cheng, W.C., Wang, S.C., Cheng, H.T., Chen, C.R., Shu, W.Y., Tsai, M.L., Hseu, R.S., Chang, C.W., Huang, C.Y., Fang,.S.H. and Hsu, I.C. Gene Expression Profiling of Dendritic Cells in Different Physiological Stages under Cordyceps sinensis Treatment. PLoS One 7(7):e40824, 2012 (Jul).
20. Huang, H. L., Chiang, L. W., Chen, J. R., Yang, W. K., Jeng, K. C., Chen, J. T., Duh, T. S., Lin, W. J., Farn, S. S., Chiang, C. S., Huang, C. W., Lin, K. I. and Yu, C. S. Study of [18F]FLT and [123I]IaraU for cellular imaging in HSV1 tk-transfected murine fibrosarcoma cells: Evaluation of the tracer uptake using 5-fluoro, 5-iodo and 5-iodovinyl arabinosyl uridines as competitive probes. Nucelar Medicine and Biology 39(3): 371-376, 2012 (April).
21. Lin, K. J., Wu, C. C., Pan, Y. H., Chen, F. H., Fu, S. Y., Chiang, C. S., Hong, J. H. and Lo, J. M. In vivo imaging of radiation-induced tissue apoptosis by 99mTc(I)-his6-annexin A5. Annals of Nuclear Medicine 26 (3): 272-280, 2012 (April).
22. Wang, S. C., Hong, J. H., Hsueh, C. and *Chiang, C. S. Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model. Laboratory Investigation 92(1): 151-162, 2012 (Jan).
23. Huang, C. L., Shu, W. Y., Tsai, M. L., Chiang, C. S., Chang, C. W., Chang, C. T. and Hsu, I. C. Repeated small perturbation approach reveals transcriptomic steady states. PLoS One 6(12): e29241, 2011 (Dec.).
24. Huang, W. C., Chiang, W. H., Huang, Y. F., Lin, S. C., Shih, Z. F., Chern, C. S., Chiang, C. S. and Chiu, H. C. Nano-scaled pH-responsive polymeric vesicles for intracellular release of doxorubicin. Journal of Drug Targeting 19(10): 944-953, 2011 (Dec.)
25. Luo, W.Y., Shih, Y.S., Lo, W.H., Chen, H.R., Wang, S.C., Wang, C.H., Chien, C.H., Chiang, C.S., Chuang, Y.J. and Hu, Y.C.. Baculovirus vectors for antiangiogenesis-based cancer gene therapy. Cancer Gene Ther. 18 (9): 637-645, 2011 (Sep.)
26. Chen, F. H., Chiang, C. S., Wang, C. C., Fu, S. F., Tsai, C. S., Jung, S. M., Wen, C. J. Lee, C. C. and Hong, J. H. Vasculatures in tumors growing from pre-irradiated tissues: formed by vasculogenesis and resistant to radiation and anti-angiogenic therapy. Int. J. Radiation Oncology Biol. Phys. 80 (5):1512 - 1521, 2011 (Aug)
27. Chen, J. J., Chen, J. J. J., Chiang, C. S., Hong, J. H. and Yeh, J. K. Assessment of tumor vasculature for diagnostic and therapeutic applications in a mouse model in vivo using 25-MHz power Doppler imaging. Ultrasonics 51: 925 – 931, 2011 (May).
28. Wang, S. C., Wu, C. C., Wei, Y. Y., Hong, J. H. and *Chiang, C. S. Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells. Inter J. Radiat. Biol. 87(4): 432-42, 2011 (Apr) IF:2.275 (1/35 in NUCLEAR SCIENCE & TECHNOLOGY)
29. Li, C. Y,.Chao, L. P.,Wang, S. C.,Chang, H. Z., Tsai, M. L., Fang, S. H., Liao, P. C., Ho, C. L., Chen, S. T., Cheng, W. C., Chiang, C. S., Hua, K. F. and Hsu, I. C. Honokiol Inhibits LPS-induced Maturation and Inflammatory Response of Human Monocyte-derived Dendritic Cells J. Cellular Physiology 226(9):2338-49, 2011 (Sep.)
30. Hwang, K. C., Lai, P. D.,Chiang, C. S.,Wang, P. J., Jun-Jye Yuan, J. J. Neutron Capture Nuclei-Containing Carbon Nanoparticles for Destruction of Cancer Cells. Biomaterials 2010, 31(32):8419 -25. IF: 7.36
http://www.ncbi.nlm.nih.gov/pubmed/20701966
31. Yang, T.S., Cuin, Y., Wu, C. M., Lo, J. M., Chiang, C. S., Shu, W. Y., Chung, W. J., Yu, C. S., Chiang, K. N., and Hsu, I. C. Determining the Zero-Force Binding Energetics of Intercalated DNA Complex Using Single Molecule Approach. ChemPhysChem. 2009, 10(16):2791-2794 (Nov.). IF:3.5 (2/32 in PHYSICS, ATOMIC, MOLECULAR & CHEMICAL
32. Li, C. Y., Chiang, C. S., Tsai, M. L., Hseu, R. S., Shu, W. Y., Sun, Y. C., Chang, Y. S., Lin, J. G., Chen, C. S., Chuang, C. Y., and Hsu, I. C. Two-sided effect of Cordyceps sinensis on dendritic cells in different physiological stages. J. Leu. Biol. 2009, 85(6):987-995 (June). IF: 4.128 (25/119 in Imunolog
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19261928
33. Tsai, M. L., Chang, K. Y., Chiang, C. S., Shu, W. Y., Weng, T. C., Chen, C. R., Lin, H. K., Huang, C. L., and Hsu, I. C. UVB induces persistent activation of ribosome and oxidative phosphorylation pathways. Radiat. Res. 2009, 171(6): 716-724 (June) IF: 2.599 (18/70)
34. Chen, F. H., Chiang, C. S., Wang, C. C., Tsai, C.S., Jung, S. M., Lee, C. C., McBride, W. H., and Hong, J. H. Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumors. Clinic. Cancer Res. 2009, 15 (5):1721 – 1729 (March). IF: 6.250 (15/132)
35. Chang, I. P., Hwang, K. C., and Chiang, C. S. Preparation of Fluorescent Magnetic Nanodiamonds and Cellular Imaging. J. Am. Chem. Soc. 2008, 130(46):15476-15481 (Nov.). IF: 7.889 (7/127)
36. Liu, W. C., Chuang, W. L., Tsai, M. L., Hong, J. H., McBride, W. H., and Chiang, C. S. Cordyceps sinensis health supplement enhances recovery from taxol-induced leucopenia. Exp. Bio. Med. 2008, 233(4): 447-455 (April). IF:1.979 (37/81 in MEDICINE, RESEARCH & EXPERIMENTAL)
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18367634
37. Chiang, C. S., Chen, F. H., Hong, J. H., Jiang, P.S., Huang, H. L., Wang, C. C., and McBride, W. H. Functional phenotype of macrophages depends on assay procedures. International Immunology 2008 (Feb), 20 (2): 215-222. IF:3.290 (43/119 in Immunology)
38. Chiang, C. S., Yu, C. F., Chiang, L. W., Chen, S. W., Lo, J. M., Yu, C. S. Comparison of bioactivities of 5-fluoro, 5-iodo, 5-iodovinyl, and 5-fluorovinyl arabinosyl uridines against SR-39 TK-transfected murine prostate cancer cells. Chem. Pharm. Bull. 2008 (Jan), 56 (1): 109-111. IF:1.223 (18/41 in CHEMISTRY, MEDICINAL)
39. Tsai ,C.S., Chen, F.H., Wang, C.C., Huang, H.L., Jung, S. M., Wu, C. J., Lee, C. C., McBride, H. W., Chiang, C. S., and Hong, J. H. Macrophages from irradiated tumors express higher levels of inos, arginase-I and cox-2, and promote tumor growth. Int. J. Radiation Oncology Biol. Phys. 2007 (June), 68(2):499-507 IF:4.290) (6/87 in RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING)
40. Liu, W.C., Wang, S.C., Tsai, M.L., Chen, M.C., Wang, Y.C., Hong, J.H., McBride, W.H., and Chiang, C.S. Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis – a Chinese herbal medicine. Radiation Research. 2006 (Dec.), 166(6):900-907.
41. Tsai, C.H., Hong, J.H., Hsieh, K.F., Hsiao, H.W., Chuang, W.L., Lee, C.C., McBride, W.H., and Chiang, C.S. Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer. Cancer Gene Therapy. 2006 (Dec.), 13 (12):1082-1092
42. Chiang, C.S., Liu, W.C., Jung, S.M., Chen, F.H., Wu, C.R., McBride, W.H., Lee, C.C., and Hong, J.H. Compartmental responses after thoracic irradiation of mice: strain differences. Int. J. Radiation Oncology Biol. Phys. 2005, 62 (3):862–871
43. Henke, A., Chiang, C.S, Zell, R., and Stelzner, A. Co-expression of interleukin-2 to increase the efficacy of DNA vaccine-mediated protection in coxsackievirus B3-infected mice. Antiviral Res. 2004 (Nov.), 64(2):131-136
44. McBride, W. H., Chiang, C. S., Olson, J. L., Wang, C. C., Hong, J. H., Pajonk, F., Dougherty, G. J., Iwamoto, K. S., Pervan, M. Liao, Y. P. A sense of danger from radiation. Radiat. Res. 2004 (July), 162 (1): 1–19
45. Hong, J. H., Jung, S. M. , Tsao, T. C. Y., Wu, C. J., Lee, C. Y., Chen, F. H., Hsu, C. H., McBride, W. H., and Chiang, C. S. Bronchoalveolar lavage and interstitial cells have different roles in radiation-induced lung injury. Inter. J. Radiat. Biol. 2003 (March), 79 (3): 159-167
46. McBride, W. H., Pajonk, F., Chiang, C. S., and Sun, J. R. NF-kappa B, cytokines, proteasomes, and low-dose radiation exposure. Mil. Med. 2002 (Feb.), 167 (2 Supp): 66 – 67
47. Daigle, J. L., Hong, J. H., Chiang, C. S., and McBride, W. H. The Role of Tumor Necrosis Factor Signaling Pathways in the Response of Murine Brain to Irradiation. Cancer Research, 2001 (Dec.), 61: 8859 – 8865
48. Hong, J. H., Chiang, C. S., Tsao, C. Y., Lin, P. Y., Wu. C. R., and McBride, W. H. Can short-term administration of dexamethason abrogate radiation-induced acute cytokine gene response in lung and modify subsequent molecular responses? Int. J. Radiat. Oncol. Biol. Phys., 2001 (Oct.), 51:296-303
49. Wu, Y. Z., Hong, J. H., Huang, H. H., Dougherty, J. G., McBride, W. H., and Chiang, C. S. Mechanisms mediating the effects of IL-3 gene expression on tumor growth. J. Leukocyte Biology, 2000 (Dec.), 68(6): 890-896
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=11129657
50. Chiang, C. S., Hong, J. H., Wu, Y. C., McBride, H. W., and, Dougherty, J. G. Combining radiation therapy with IL-3 gene immunotherapy. Cancer Gene Therapy, 2000 (Aug), 7(8) 1172-1178
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10975678
51. Hong, J. H., Chiang, C. S., Tsao, C. Y., Lin, P. Y., McBride, W. H., Wu, C. J. Rapid induction of cytokine gene expression in lung after single and fractionated doses of radiation. International Journal of Radiation Biology, 1999 75:1421-1427 (Nov.)
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10597915
52. Powell, H. C., Garrett, R. S., Brett, F. M., Chiang, C. S., Chen, E., Masliah, E., and Campbell, I. L. Response of glia, mast cells and the blood brain barrier, in trasgenic mice expressing interleukin-3 in astrocytes, an experimental model for CNS demyelination. Brain Pathology 9:219-236, 1999 (Apr.)
53. Chiang, C. S., Sawyers, C. L., and McBride, W. H. Oncogene expression and cellular radiation resistance: A modulatory role of c-myc. Molecular Diagnosis 3(1): 21-29, 1998 (March)
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=10096954
54. Chiang, C. S., Syljuåsen, R. G., Hong, J. H.,Wallis, A., Dougherty, G. J., and McBride, W. H. Effect of IL-3 gene transduction on tumor response to irradiation in vitro and in vivo. Cancer Res. 57(18): 3899-3903, 1997 (Sep.)
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9307268
55. Stalder, A. K., Pagenstecher, A., Yu, N. C., Kincaid, C., Chiang, C. S., Hobbs, M. V., Bloom, F. E., and Campbell, I. L. Lipopolysaccharide induced interleukin-12 expression in the CNS and cultured astrocytes and microglia. J. of Immunology 159 (15): 1344-1351 , 1997 (Aug.)
56. Chiang, C. S., Hong, J. H., Stalder, A., Sun, J. R., Withers, H. R., and McBride, W. H.. Late-delayed molecular responses to brain irradiation. Inter. J. Radiat. Biol. 72 (1):45-53., 1997 (July)
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9246193
57. Campbell, I. L., Stalder, A. K., Chiang, C. S., Steffensen, S., Henriksen, S., Bellinger, B.,Siggins, G.,Heyser, C.,Masliah, E., Powell, H., and Gold, L. H. Transgenic models to assess the pathogenic actions of cytokines in the central nervous system. Mol. Psychiatry 2(2):125-129, 1997 (March).
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9106234
58. Hong, J. H., Chiang, C. S., Sun, J. R., Withers, H. R., and McBride, W. H. Induction of c-fos and jun -B mRNA following in vivo brain irradiation. Molecular Brain Research 48 (2): 223-228, 1997
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=9332719
59. Gold, L. H., Heyser, C.J., Roberts, A.J., Henriksen, S.J., Steffensen, S.C., Siggins, G.R., Bellinger, F.P., Chiang, C. S., Powell, H.C., Masliah, E., et al. Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice. Adv. Exp. Med. Biol., 402:199-205, 1996
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8787661
60. McBride, W. H., Economou, J. S., Syljuasen, R., Parrish, C., Hackman, D., Latham, V., Chiang, C. S., and Dougherty, G. J. The effects of cytokine gene tranfer into tumor on host cell infiltration and regression. Anticancer Res. 16: 1139-1144, 1996
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8702225
61.Chiang, C. S., Samimi, A., Powell, H. C., Gold, L. and Campbell, I. L. Macrophage/microglia-mediated primary demyelination and motor disease induced by the CNS production of interleukin-3 in transgenic mice. J. Clinc. Invest. 97: 1512 - 1524, 1996 .
http://www.ncbi.nlm.nih.gov/htbin-post/Omim/getmim%3ffield=medline_uid&search=8617885
62. McBride, W. H., Economou, J. S., Kuber, N., Hong, J. H., Chiang, C. S., Syljuasen, R. G., Dougherty, S. T. and Dougherty, G. J. Modification of tumor microenviroment by cytokine gene transfer. Acta Oncol. 34(3):447-451, 1995
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7779438
63. Hong, J. H., Chiang, C. S., Campbell, I. L., Withers, H. R. and McBride, W. H. Induction of acute-phase gene-expression by brain irradiation. Int. J. Radiat. Oncol. Biol. Phys. 33:619-626, 1995
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7558951
64. Campbell, I. L. and Chiang, C. S. Cytokine involvement in CNS disease: implications from trangenic mice. Ann. N.Y. Acad. Sci. 771: 310-312, 1995
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8597408
65. McBride, W. H., Dougherty, G. D., Wallis, A. E., Economou, J. S., and Chiang, C. S. Interleukin-3 in gene therapy of cancer, Folia Biol. 40: 62-73, 1994.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7958065
66. Hong, J. H., Gatti, R. A., Huo, Y. K., Chiang, C. S., and McBride, W. H. G2/M-phase arrest and release in ataxia telangiectasia and normal cells after exposure to ionizing radiation, Radiat Res. 140: 17-23, 1994.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7938450
67. Chiang, C. S., Stalder, A., Samimi, A., and Campbell, I. L. Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice, Dev Neurosci. 16: 212-21, 1994.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7535683
68. Campbell, I. L., Samimi, A., and Chiang, C. S. Expression of the inducible nitric oxide synthase. Correlation with neuropathology and clinical features in mice with lymphocytic choriomeningitis, J Immunol. 153: 3622-9, 1994.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7523499
69. Mason, K. A, Withers, H. R., and Chiang, C. S. Late effects of radiation on the lumbar spinal cord of guinea pigs: re-treatment tolerance, Int J Radiat Oncol Biol Phys. 26(4):643-648, 1993
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8330995
70. Chiang, C. S., McBride, W. H., and Withers, H. R. Myelin-associated changes in mouse brain following irradiation, Radiother Oncol. 27: 229-36, 1993
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=7692473
71. Chiang, C. S., McBride, W. H., and Withers, H. R. Radiation-induced astrocytic and microglial responses in mouse brain, Radiother Oncol. 29: 60-8, 1993.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=8295989
72.
Chiang, C. S.,
Mason, K. A., Withers, H. R., and McBride, W. H. Alteration in myelin-associated
proteins following spinal cord irradiation in guinea pigs
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1280252
73. Chiang, C. S. and McBride, W. H. Radiation enhances tumor necrosis factor alpha production by murine brain cells, Brain Res. 566: 265-9, 1991.
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&dopt=r&uid=1814542
B. Book Section:
1. McBride, W. H., Dougherty, G. J., Syljuasen, R., Chiang, C. S., and Daigle, J. L. New molecular and genetic approaches aimed at improving radiation therapy. In Progress in Radio-Oncology Vol. VI, Kogelnik, H. D., and Seldmayer, F. eds. Monduzi Editore S.p. A. – Bologna (Italy), pp. 27-33, 1998
2. McBride, W. H., Chiang, C. S., Hong, J. H., and Withers, H. R. Molecular and celluar responses of the brain to radiotherapy. In Progress in Anti-Cancer Chemotherapy, Vol. 1 Khayat, D. and Hortobagyi, G. N. eds. Blackwell Science Ltd. MA, Chap. 6, pp.91 – 132, 1997
3. Gold, L. H., Heyser, C. H., Roberts, A. J., Henriksen, S. J., Steffensen, S. C., Siggins, G. R., Bellinger, F. P., Chiang, C. S., Powell, H. C., Masliah, E., and Campbell, I. L. Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice. In AIDS, Drugs of Abuse, and the Neuroimmune Axis, Friedmann et all eds. Plenum Press, New York, Chap. 26. pp. 199 – 205, 1996
4. Chiang, C. S., Dougherty, G. J., Economou, J. S. and McBride, W. H. Tumor-directd cytokine gene therapy. In Gene therapy - from laboratory to the clinic, K. M. Hui, eds. World Scientific Publishing Co. Pte. Ltd., New Jersey, pp. 20-44. 1994
5. McBride, W. H. and Chiang, C. S. The response of normal brain tissue to irradiation. In Stereotatctic surgery and radiosurgery, A. A. F. De Salles and S. J. Goetsch, eds. Medical Physics Publishing, Wisconsin, pp. 159-167. 1993
