俞鐘山  Chung-Shan Yu

 

醫藥化學實驗室

Medicinal  Chemistry Laboratory

 

  Early diagnosis of cancer is the best way to beat cancer. Through the use of PET (positron emission tomography) and SPECT (single-photon emission computed tomography), cancer-targeted radiolabeled molecules can be monitored by non-invasive imaging for diagnosis. In order to develop cancer-targeted radiolabeled molecules efficiently, rapid parallel synthesis of solution-phase derived libraries followed by their in situ cell-based screening is an innovative approach. The core structures constitute natural product-like and drug-like molecules, e.g. nucleoside, glycoside, glycosphingolipid, ceramide, ethacrynic amide, fenbufen amide, glutathione and cyclic peptide. Molecules tagged with ultrahigh sensitive radionuclides e.g. fluorine-18 and iodine-123 have been intensively studied in this laboratory. Liver multidrug-resistant enzyme and cyclooxygenase might be targeted as a biomarker for cancer therapy using our newly developed 18F- and 123I- labeled new compounds. The data of pharmacokinetics will be useful for preclinical as well as clinical studies in the future.

 

 

 

 

 

Selected Publications

1.Huang, H.-L.; Chiang, L.-W.; Chen, J.-R.; Huang, C.-W.; Yang, W.-K.; Chiang, C.-S.; Jeng, K.-C.; Lin, W.-Z.; Fan, S.-S.; Chen, J.-Z.; Yu, C.-S.* "Study of [18F]FLT and [123I]IaraU for cellular imaging in HSV1 tk-transfected murine fibrosarcoma cells: Evaluation of the tracer uptake using 5-fluoro, 5-iodo and 5-iodovinyl arabinosyl uridines as competitive probes", Nucl. Med. Biol. In press, 2011, xx-xx.

2.Su, Y.-H.; Chiang, L.-W.; Jeng, K.-C.; Huang, H.-L.; Chen, J.-Z.; Lin, W.-Z.; Huang, C.-W.; Yu, C.-S.*, "Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries", Bioorg. Med. Chem. Lett. 2011, 21, 1320-1324.

3.Lin, K.-I.; Yang, C.-H.; Huang, C.-W.; Jian, J.-Y.; Huang, Y.-C.*; Yu, C.-S.*, "Synthesis and structure-activity relationships of fenbufen amide analogs", Molecules 2010, 15, 8796-8803.

4.Chiang, L.-W.; Pei, K.; Chen, S.-W.; Huang, H.-L.; Lin, K.-J.; Yen, T.-C.; Yu, C.-S.*, "Combining a solution-phase derived library with in-situ cellular bioassay: Prompt screening of amide-forming minilibraries using MTT assay", Chem. Pharm. Bull. 2009, 57, 714-718.

5.Yu, C.-S.*; Wang, R.-T.; Chiang, L.-W.; Lee, M.-S., "Synthesis of 4',4'-C-diaminomethyl nucleoside derivative as a building block for constructing libraries via amide bond formation.", Tetrahedron Lett. 2007, 48, 2979-2982.

6.Yu, C.-S.*; Wang, H.-Y.; Chiang L.-W.; Pei, K., "Synthesis of rhamnosyl trisaccharide repeating unit to mimic the antigen determinant of Pseudomonas syringae lipopolysaccharide.", Synthesis 2007, 1412-1420.

7.Yu, C.-S.*; Chiang, L.-W.; Wu, C.-H.; Hsu, Z.-K.; Lee, M.-H.; Pan, S.-D.; Pei, K., "Syntheses of 5-fluoro and (E)-5-(2-fluorovinyl) arabinosyl uridine analogues as potential probes for the HSV-1 thymidine kinase gene", Synthesis 2006, 3835-3840.

8.Yu, C.-S.*; Chiang, L.-W.; Wu, C.-H.; Wang, R.-T.; Chen, S.-W.; Wang, H.-Y.; Yeh, C.-H., "Synthesis of 5-radioiodoarbinosyl uridine   analogs for Probing HSV TK gene: An unexpected chelating effect", Nucl. Med. Biol. 2006, 33, 367-370.

 

  2008 – Present Associate Professor

   Department of Biomedical Engineering

   and Environmental Sciences, National

   Tsing Hua University, Taiwan

  2003 2008 Assistant Professor

   Department of Nuclear Science,

   National Tsing Hua University, Taiwan

  1999 2003 Post-doctoral Fellowship

   Department of Chemistry, Academia

   Sinica, Taiwan

  1995 1999 PhD in Organic Chemistry

   Department of Chemistry, Heidelberg

   University, Germany

  1994 1995 MS in Organic Chemistry

   Department of Chemistry, Heidelberg

    University, Germany

  1993 1994 Reaserch Assistant

   PET/Cyclotron Center, Taipei Veterans 

   General Hospital, Taiwan

  1989 1991 MS in Radiochemistry

   Department of Chemistry, National Tsing 

   Hua University, Taiwan

  1985 1989 Bachelor in Chemistry

   Department of Chemistry, Tamkang

   University, Taiwan

 

研究興趣

   

u醫藥化學

u分子影像

u放射藥物

 

 

Research Interests

   
uMedicinal Chemistry
uMolecular Imaging
uRadiolabeled Compounds

TEL 886-3-5715131 ext 35582
FAX :886-3-5718649

E-mail csyu@mx.nthu.edu.tw

http://mx.nthu.edu.tw/~csyu/