俞鐘山      Chung-Shan, Yu

Education

Heidelberg University, Germany, Ph. D., 1995-1999, Organic chemistry

Heidelberg University, Germany, Master, 1994-1995,Organic chemistry

National Tsinghua University, Taiwan, Master, 1989-1991, Radiochemistry

Tamkang University, Taiwan, Bachelor, 1985-1989, Chemistry

一、期刊論文

1. Li-Wu Chiang, Kai Pei, Shao-Wei Chen, Ho-Lien Huang, Kun-Ju Lin, Tzu-Chen Yen, and Chung-Shan Yu* “
   Combining a solution-phase derived library with in-situ cellular bioassay: Prompt screening of amide-forming minilibraries using MTT assay”Chem. Pharm. Bullet. (In press) 2009.

2. Jem-Mau Lo, Li-Wu Chiang, Shao-Wei Chen, Zhi-Wei Fu, Kai Pei, Chung-Shan Yu* “Recent advances in solution-phase derived synthetic libraries and rapid bioassays on microtiter plates” Invited review paper for publication in Chim. Oggi. 2007, 25, 46-50. (SCI) (國科會計劃NSC 95-2113-M-007-039)

3. Chi-Shiun Chiang, Ching-Fang You, Li-Wu Chiang, Shao-Wei Chen, Jem-Mau Lo, Chung-Shan Yu* “Comparison of bioactivities of 5-fluoro, 5-iodo, 5-iodovinyl, and 5-fluorovinyl arabinosyl uridines against SR-39 TK-transfected murine prostate cancer cells” Chem. Pharm. Bullet. Accept. 2007 (SCI) (國科會計劃 NSC-96-2113-M-007-028-MY2)

4. Chien-Hung Yeh, Si-Der Pan, Shao-Wei Chen, Zhi-Wei Fu, Li-Wu Chiang, Chung-Shan Yu* “An improved method for synthesis of ceramide for constructing a-galactosyl ceramide analogs.” J. Chin. Chem. Soc. Taipei. accepted. 2007(SCI) (國科會計劃 NSC 95-2113-M-007-039)

5. Chung-Shan Yu*, Ren-Tsong Wang, Li-Wu Chiang, Ming-Shun Lee “Synthesis of 4',4'-C-diaminomethyl nucleoside derivative as a building block for constructing libraries via amide bond formation.” Tetrahedron Lett., 2007, 48, 2979-2982. (SCI) (國科會計劃 NSC 95-2113-M-007-039)

6. Chung-Shan Yu*, Heng-Yen Wang and Li-Wu Chiang “Synthesis of rhamnosyl trisaccharide repeating unit to mimic the antigen determinant of Pseudomonas syringae lipopolysaccharide.” Synthesis, 2007, 1412-1420. (SCI) (國科會計劃 NSC 95-2113-M-007-039)

7. Kun-I Lin, Li-Wu Chiang, Chien-Hung Wu, Shao-Wei Chen, Chung-Shan Yu* “Synthesis of 5-radioiodoarabinosyl uridine analog for probing HSV-1 thymidine kinase gene.” J. Chin. Chem. Soc. Taipei. 2007, 54, 563-568. (SCI) (國科會計劃 NSC 94-2113-M-007-005)

8. Chung-Shan Yu*, Chien-Hung Wu, Li-Wu Chiang, Kai Pei and Zhi-Kai Hsu, “Synthesis of (E)-5-(2-fluorovinyl)arabinosyl uridine analog as a potential probe for HSV-1 thymidine kinase gene” Synthesis, 2006, 3835-3840 (SCI). (國科會計劃 NSC 94-2113-M-007-005).

9. Li-Wu Chiang, Jem-Miao Lo, Chung-Shan Yu*, “Synthesis of Rradiolabeled Nucleoside Analogs for Probing Cancer Gene Therapy” Chemistry (The Chem. Soc., Taipei), 2006, 64, 179-190 (Review Article in Chinese) (國科會計劃 93-2113-M-007-038)

10. Chung-Shan Yu*, Li-Wu Chiang, Chien-Hung Wu, Ren-Tsong Wang, Shao-Wei Chen, Heng-Yen Wang, and Chien-Hung Yeh, “Synthesis of 5-radioiodoarbinosyl uridine analogs for Probing HSV TK gene: An unexpected chelating effect” Nucl. Med. Biol. 2006, 33, 367-370 (SCI). (國科會計劃 93-2113-M-007-038).

11. Chung-Shan Yu*, Chien-Hung Wu, Li-Wu Chiang, Ren-Tsong Wang, Heng-Yen Wang, Chien-Hung Yeh, and Kun-I Lin, “Synthesis of (E)-5-(2-radioiodovinyl)arabinosyl Uridine Analog for Probing HSV-1 Thymidine Kinase Gene” Chemistry Letters 2005, 34 (10), 1390-1391 (SCI). (國科會計劃 NSC 93-2113-M-007-038).

12. Yu, C.-S.*; Oberdorfer, F. “Synthesis of a Novel Aldehyde: 4-O-methyl-5-formylmethyl-2’-deoxyuridine Derivatives” Nucleosides, Nucleotides Nucleic Acids 2003, 22 (1), 71-84.

13.  Yu, C.-S.*; Zeisler, S.; Eisenbarth, J.; Weber, K.; Runz, A.; Oberdorfer, F. “Synthesis of 5-(2-radiohaloethyl)- and 5-(2-radiohalovinyl)-2’-deoxyuridines. Novel Types of Radiotracer for Monitoring Cancer Gene Therapy with PET” J. Labelled Compd. Radiopharm. 2003, 46, 1-19.

14. Yu, C.-S.; Niikura, K.; Lin, C.-C.*; Wong, C.-H*. “The Thioglycoside and Glycosyl Phosphite of 5-Azido Sialic Acid: Excellent Donors for the a-Glycosylation of Primary Hydroxy Groups” Angewandte Chemie 2001, 40, 86-88.

15. C.-S Yu, F. Oberdorfer* “Synthesis of (E)-5-[2-(tri-n-butylstannyl)vinyl] substituted 2’-deoxyuridine derivatives for use in halogenation and radiohalogenation reactions” Synlett 2000, 86-88.

16. C.-S. Yu, F. Oberdorfer* “Synthesis of 4-O-methyl-protected 5-(2-hydroxyethy)-2’-deoxyuridine derivatives and their nucleophilic fluorination to 5-(2-fluoroethyl)-2’-deoxyuridine” Synthesis 1999, 2057-2064.

二、會議論文

1.      Invitation as a speaker for Discovery Chemistry Congress Organized by Select Biosciences San Franscisco 2007, Oct.

2.      Chung-Shan Yu*, Ren-Tsong Wang, Li-Wu Chiang, Kai Pei, Ho-Lien Huang, and Ming-Hsun Lee. Synthesis of 4',4'-C-diaminomethyl nucleoside derivative as a building block for constructing libraries via amide bond formation. 233^th American Chemical Society Spring Meeting; Chicago 25-29 March. 2007.

3.      Chung-Shan Yu*, Chien-Hung Yeh, Li-Wu Chiang, Si-Der Pan, and Kai-Hsiang Chang. An improved method for synthesis of ceramide for constructing alpha-galactosyl ceramide analogs. 233^th American Chemical Society Spring Meeting; Chicago 25-29 March. 2007.

4.      Chung-Shan Yu*, Heng-Yen Wang, Li-Wu Chiang, Shao-Wei Chen, and Chen-Tze Pan. Synthesis of rhamnosyl trisaccharide repeating unit to mimic the antigen determinant of Pseudomonas syringae lipopolysaccharide. 233^th American Chemical Society Spring Meeting; Chicago 25-29 March. 2007.

5.      Chung-Shan Yu*, Heng-Yen Wang and Li-Wu Chiang. Synthesis of rhamnosyl trisaccharide repeating unit to mimic the antigen determinant of Pseudomonas syringae lipopolysaccharide. ICCEOCA-1 post-conference of 1^st international conference on cutting edge organic chemistry in asia. 2006, Oct. 21-24, Hsinchu Taiwan.

6.      Chung-Shan Yu*, Chien-Hung Yeh, Li-Wu Chiang. Synthesis of amide-bond nucleoside analogs for construction of libraries to develop HSVtk gene probes efficiently. 2^nd Symposium of biomedical imaging and radiological sciences. Taiwan Sept. 24, 2006. Taipei Taiwan.

7.      Yu, C.-S.*; Chiang, L.-W.; Wu, C.-H; Wang, R.-T; Wang, H.-Y.; Yeh, C.-H.; Hsu, Zhi-Kai Synthesis of (E)-5-(2-fluorovinyl)arabinosyl uridine analog as a potential probe for HSV-1 thymidine kinase gene SNM 53rd Annual Meeting; San Diego 3-7 June. 2006. SCI (NSC 94-2113-M-007-005).

8.      Chiang, L.-W.; Wu, C.-H; Wang, R.-T; Wang, H.-Y.; Yeh, C.-H.; Yu, C.-S.* Development of gene probes. Synthesis of radioiodo and radioiodovinyl arabinosyl uridine analogs 229^th American Chemical Society Spring Meeting; San Diego 13-17 March. 2005, 229, U165-U165. SCI (NSC 93-2113-M-007-038).

9.      Chien-Hung Wu (吳建宏), Li-Wu Chiang (姜豊武), Kai Pei (裴鍇), Zhi-Kai Hsu (許智凱) and Chung-Shan Yu (俞鐘山)* Synthesis of (E)-5-(2-fluorovinyl)arabinosyl uridine analog as a potential probe for HSV-1 thymidine kinase gene Chinese Chemical Society annual meeting November 19-20, 2005, Kaoshiung, Taiwan. (國科會計劃 NSC-94-2113-M-007-005)

10.  Chung-Shan Yu*, Li-Wu Chiang, Chien-Hung Wu, Ren-Tsong Wang, Heng-Yen Wang, Chien-Hung Yeh, Development of gene probes. Synthesis of radioiodo and radioiodovinyl arabinosyl uridine analogs, American Chemical Society national meeting, San Diego, CA, March 13-17, 2005 (國科會計劃 NSC 93-2113-M-007-038)

11.  Li-Wu Chiang (姜豊武), Chien-Hung Wu (吳建宏), Ren-Tsong Wang (王仁聰), Chien-Hung Yeh (葉建宏), Shi-Ting Huang (黃詩婷), Chung-Shan Yu (俞鐘山)* Development of gene probes. 1. Synthesis of radioiodo arabinosyl uridine analog Chinese Chemical Society annual meeting November 25-26, 2004, Taichung, Taiwan. (國科會計劃 NSC 93-2113-M-007-038)

12.  Chien-Hung Wu (吳建宏), Li-Wu Chiang (姜豊武), Heng-Yen Wang (王姮雁) , Shao-Wei Chen (陳劭維), Chung-Shan Yu (俞鐘山)* Development of gene probes. 2. Synthesis of 5-(2-radioiodovinyl) arabinosyl uridine analog Chinese Chemical Society annual meeting November 25-26, 2004, Taichung, Taiwan. (國科會計劃 NSC 93-2113-M-007-038)

13.  Yu, C.-S.; Lin, C.-C. and Wong, C.-H. 5-Azido sialic acid as new glycosylation reagent- An excellent a-selectivity donor GLYCO XVI: XVI International Symposium on Glycoconjugates; The Hague, The Netherlands August 19-24, 2001 (Academia Sinica).

14.  Yu, C.-S.*; Zeisler, S.; Eisenbarth, J.; Weber, K.; Runz, A.; Oberdorfer, F. Synthesis of 5-(2-radiohaloethyl)- and 5-(2-radiohalovinyl)-2-deoxyuridines for use in monitoring Gene Therapy XII th International Symposium on Radiopharmaceutical Chemistry; Uppsala, Sweden June 15-19, 1997.