在科學發展的過程中，不論是在材料、環境或物醫學等相關的科技研究中，分析化學一直扮演著一相當重要的角色，從分析化學所提供的分析監控資訊，不但可以了解不同樣品中各種成份分佈的情況，更可藉此改善產品或環境品質，進而提高產品的生產效率或增進人類的健康。

    現代科學技術對分析數據的需求，也不再侷限於"是什麼"和"有多少"，而是要求提供更多的，更全面的訊息，從常量(Major)到微量(Minor)分析；從組成(Component)到組成物種(Species)分析；從整體(Bulk)到微區(Micro-area)，表面(Surface)及層次(Depth-profile)分佈分析；從巨觀(Macro)的組成到微觀(Micro)的結構；從靜態到快速反應追蹤分析；從破壞試樣到非破壞分析；從非線上(Off-line)到線上(On-line)分析等等。

    近年來，本實驗室為滿足現代科學在了解微量元素及其物種在不同載體（環境介質，工業材料，生物組織）中所扮演角色的需求，目前的研究方向包括：

    (1)奈米光觸媒技術在分析化學上的應用

   

　

(2)3D列印技術在分析化學上的應用

　

(3)各式微流體晶片製作技術在分析化學上的應用

　

(4)活體動物體內及環境水樣中微量元素及其物種線上連續及動態分析技術

　

(5)活體動物體內及環境水樣中奈米粒子及其溶解產物線上連續及動態分析技術

        

     

　

    

     

    

    

     

　

     

　

　

     

    

　

                                                                                                                                                                                                                                                                                                                          

　

104/碩士/曾柏仁/線上監測腫瘤組織間液內金奈米粒子、過氧化氫、乳酸與葡萄糖之連線分析系統的開發與應用

102/碩士/蘇怡安/開發綠色蒸氣生成法串連高效能液相層析與感應耦合電漿質譜儀進行稻米中砷物種之連線分析研究

102/碩士/夏聖傑/利用線上樣品分段與三維列印技術開發監測活體動物腦中金屬元素動態變化趨勢的連線分析系統介面

102/碩士/陳建逸/開發二氧化鈦輔助式前濃縮暨原位蒸氣生成晶片串聯感應耦合電漿質譜儀進行尿液樣品中無機汞離子線上測定之研究

101/碩士/陳順娘/利用1,1-二氯乙烯功能化固相萃取晶片建立感應耦合電漿質譜儀連線分析系統進行天然水樣中微量元素分析之研究

101/碩士/陳震宇/開發Fenton-like催化螢光連線分析系統應用於活體動物大腦葡萄糖動態變化偵測

101/碩士/楊琇涵/利用金奈米粒子探針搭配恆溫核酸放大技術進行金黃色葡萄球菌蛋白質 A 之分析研究

100/碩士/楊承泓/建立 Nonfunctionalized PVC Bead Packed SPE-Column—ICP-MS 系統進行活體動物腦中微量元素的連續動態監測分析研究

100/碩士/陳煜/開發披覆式晶片型AuNPs/TiO2光觸媒催化還原裝置串連高效能液相層析與感應耦合電漿質譜儀進行環境水樣中無機砷物種之連線分析研究

100/博士/施宗廷/晶片型固相萃取技術開發及其在微量元素分析上的應用

100/博士/徐繹翔/利用奈米金粒子訊號放大及磁性粒子分離技術進行核酸序列及汞離子之分析研究

99/碩士/劉益宏/利用金奈米粒子探針搭配分子及原子光譜儀測定汞離子的分析研究

99/博士/蘇正寬/活體動物體內量子點及鎘離子動態變化連線分析系統的開發與應用

99/碩士/謝政娟/建立高通量固相萃取晶片搭配感應耦合電漿質譜儀之連線分析系統進行微量元素之分析研究

98/碩士/許敦傑/利用金奈米粒子探針搭配電熱式原子吸收光譜儀測定汞離子的分析研究

98/碩士/林政興/開發披覆式晶片型光觸媒輔助還原裝置串連高效能液相層析與感應耦合電漿質譜儀進行環境水樣中無機硒物種之分析研究

98/碩士/黃烱坤/開發金奈米粒子生物光學感測器進行農藥篩檢之分析研究

98/碩士/黃靖雯/建立PPP-in-tube SPE-ICP-MS連線分析系統進行活體動物肝臟細胞間液中奈米銀粒子的連續動態監測分析研究

97/碩士/陳巧于/利用奈米探針技術搭配感應耦合電漿質譜儀建立高靈敏的病毒分型及定量分析研究

97/碩士/曾文玉/建立Photocatalyst-Assisted Digestion-PMMASPE-ICP-MS連線分析系統進行環境水樣中微量元素之分析研究

97/碩士/陳威宇/建立開管式固相萃取晶片搭配感應耦合電漿質譜儀之連線分析系統進行高鹽基質微透析樣品中微量元素之分析研究

96/碩士/林晏鈴/建立Microdialysis-In-tube SPE-ICP-MS連線分析系統進行活體動物腦中微量元素的連續動態監測之分析研究

96/碩士/吳俊甫/建立線上HPLC-PMMA Chip-based Photo-Catalyst Reduction Device (PC2RD)-ICP-MS 連線系統進行環境水樣中硒物種之分析研究

96/碩士/蔡昀妮/建立線上HPLC-Photocatalyst-Assisted Digestionand Vaporization Device (PADVD)-ICP-MS連線系統進行人體尿液中硒物種之分析研究

96/碩士/施美惠/開發Microdialysis-Desalter-ICP-MS連線分析系統進行活體動物肝臟中量子點穩定性及鎘元素拮抗作用之分析研究

　

    2015

C. K. Su, and Y. C. Sun*, Considerations of Inductively Coupled Plasma Mass Spectrometry Techniques for Characterizing the Dissolution of Metal-Based Nanomaterials in Biological Tissues, J. Anal. At. Spectrom. 2015, 30, 1689–1705. Critical Review (IF: 3.466, Ranking in Analytical Chemistry: 12/74)

C. K. Su, P. J. Peng, and Y. C. Sun*, Fully 3D-Printed Preconcentrator for Selective Extraction of Trace Elements in Seawater, Anal. Chem. 2015, 87, 6945–6950. (IF: 5.636, Ranking in Analytical Chemistry: 4/74)

C. K. Su, P. J. Tseng, M. H. Lin, H. T. Chiu, A. del Vall, Y. F. Huang, and Y. C. Sun*, Online Open-Tubular Fractionation Scheme Coupled with Push–Pull Perfusion Sampling for Profiling Extravasation of Gold Nanoparticles in a Mouse Tumor Model, J. Chromatogr. A 2015, 1402, 1–7. (IF: 4.169, Ranking in Analytical Chemistry: 6/74)

C. K. Su, T. Y. Cheng, and Y. C. Sun*, Selective Chemical Vaporization of Exogenous Tellurium for Characterizing the Time-Dependent Biodistribution and Dissolution of Quantum Dots in Living Rats, J. Anal. At. Spectrom. 2015, 30, 426–434. (IF: 3.466, Ranking in Analytical Chemistry: 12/74)

T. T. Shih, I. H. Hsu, S. N. Chen, P. H. Chen, M. J. Deng, Y. Chen, Y. W. Lin, and Y. C. Sun*, A dipole-assisted solid-phase extraction microchip combined with inductively coupled plasma-mass spectrometry for online determination of trace heavy metals in natural water, Analyst2015, 140, 600–608. (IF: 4.107, Ranking in Analytical Chemistry: 7/74)

C. K. Su, C. Y. Chen, P. J. Tseng, and Y. C. Sun*, Using Copper Ions to Amplify ROS-Mediated Fluorescence for Continuous Online Monitoring of Extracellular Glucose in Living Rat Brain, Biosens. Bioelectron. 2015, 64, 535–541. (IF: 6.409, Ranking in Analytical Chemistry: 3/74)

   2014

C. K. Su, H. T. Liu, S. C. Hsia, and Y. C. Sun*, Quantitatively Profiling the Dissolution and Redistribution of Silver Nanoparticles in Living Rats Using a Knotted Reactor-Based Differentiation Scheme, Anal. Chem. 2014, 86, 8267–8274. (IF: 5.636, Ranking in Analytical Chemistry: 4/74)

C. K. Su, S. C. Hsia, and Y. C. Sun*, Three-Dimensional Printed Sample Load/Inject Valves Enabling Online Monitoring of Extracellular Calcium and Zinc Ions in Living Rat Brains, Anal. Chim. Acta 2014, 838, 58–63. (IF: 4.513, Ranking in Analytical Chemistry: 5/74)

C. K. Su, C. W. Huang, and Y. C. Sun*, In Vivo Measurement of Extravasation of Silver Nanoparticles into Liver Extracellular Space by Push-Pull-based Continuous Monitoring System, Toxicol. Lett. 2014, 227, 84–90. (IF: 3.262, Ranking in Toxicology: 21/87)

Y. R. Hsu, Y. W. Kang, J. Y. Fang, G. Y. Lee, J. I. Chyi, C. K. Chang, C. C. Huang, C. P. Hsu, T. H. Huang, Y. F. Huang, Y. C. Sun, C. H. Hsu, C. C. Chen, S. S. Li , J. A. Yeh, D. J. Yao, F. Ren, Y. L. Wang*, Investigation of C-Terminal Domain of SARS Nucleocapsid Protein–Duplex DNA Interaction Using Transistors and Binding-Site Models, Sens. Actuator B-Chem. 2014, 193, 334–339. (IF: 4.097, Ranking in Analytical Chemistry: 8/74)

C. K. Su, S. C. Hsia, and Y. C. Sun*, A High-Throughput Microdialysis–Parallel Solid Phase Extraction–Inductively Coupled Plasma Mass Spectrometry Hyphenated System for Continuous Monitoring of Extracellular Metal Ions in Living Rat Brain, J. Chromatogr. A 2014, 1326, 73–79. (IF: 4.169, Ranking in Analytical Chemistry: 6/74)

Y. N. Tsai, C. H. Lin, I. H. Hsu, and Y. C. Sun*, Sequential Photocatalyst-Assisted Digestion and Vapor Generation Device Coupled with Anion Exchange Chromatography and Inductively Coupled Plasma Mass Spectrometry for Speciation Analysis of Selenium Species in Biological Samples, Anal. Chim. Acta 2014, 806, 165–171. (IF: 4.513, Ranking in Analytical Chemistry: 5/74)

C. K. Su, C. H. Yang, C. H. Lin, and Y. C. Sun*, In-Vivo Evaluation of the Permeability of the Blood–Brain Barrier to Arsenicals, Molybdate, and Methylmercury by Use of Online Microdialysis–Packed Minicolumn–Inductively Coupled Plasma Mass Spectrometry, Anal. Bioanal. Chem. 2014, 406, 239–247. (IF: 3.436, Ranking in Analytical Chemistry: 13/74)

   2013

T. T. Shih, C. H. Lin, I. H. Hsu, J. Y. Chen, and Y. C. Sun*, Development of a Titanium Dioxide-Coated Microfluidic-Based Photocatalyst-Assisted Reduction Device to Couple High-Performance Liquid Chromatography with Inductively Coupled Plasma-Mass Spectrometry for Determination of Inorganic Selenium Species, Anal. Chem. 2013, 85, 10091–10098. (IF: 5.636, Ranking in Analytical Chemistry: 4/74)

T. T. Shih, I. H. Hsu, J. F. Wu, C. H. Lin, and Y. C. Sun*, Development of chip-based photocatalyst-assisted reduction device to couple high performance liquid chromatography and inductively coupled plasma-mass spectrometry for determination of inorganic selenium species, J. Chromatogr. A 2013, 1304, 101–108. (IF: 4.169, Ranking in Analytical Chemistry: 6/74)

W. H. Chen, I. H. Hsu, Y. C. Sun, Y. K. Wang, and T. K. Wu*, Immunocapture Couples with Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for Rapid Detection of Type 1 Dengue Virus, J. Chromatogr. A 2013, 1288, 21–27. (IF: 4.169, Ranking in Analytical Chemistry: 6/74)

Y. W. Kang, G. Y. Lee, J. I. Chyi, C. P. Hsu, Y. R. Hsu, C. H. Hsu, Y. F. Huang, Y. C. Sun, C. C. Chen, S. C. Hung, F. Ren, J. A. Yeh, and Y. L.Wang*, Human Immunodeficiency Virus Drug Development Assisted with AlGaN/GaN High Electron Mobility Transistors and Binding-Site Models, Appl. Phys. Lett. 2013, 102, 173704.  (IF: 3.302, Ranking in Applied Physics: 21/143)

C. K. Su, and Y. C. Sun*, In Vivo Monitoring of Distributional Transport Kinetics and Extravasation of Quantum Dots in Living Rat Liver, Nanotechnology 2013, 24, 165101. (IF: 3.821, Ranking in Nanoscience & Nanotechnology: 25/79)

C. C. Huang, G. Y. Lee, J. I. Chyi, H. T. Cheng, C. P. Hsu, Y. R. Hsu, C. H. Hsu, Y. F. Huang, Y. C. Sun, C. C. Chen, S. S. Li, J. A. Yeh, D. J. Yao, F. Ren, and Y. L. Wang*, AlGaN/GaN High Electron Mobility Transistors for Protein-Peptide Binding Affinity Study, Biosens. Bioelectron. 2013, 41, 717–722. (IF: 6.409, Ranking in Analytical Chemistry: 3/74)

C. W. Liu, C. P. Hsu, J. A. Yeh, Y. C. Sun, Y. F. Huang, B. H. Chu, F. Ren, and Y. L. Wang*, Light-Actuated Water Droplet Motions on ZnO Nanorods, Microsyst. Technol. 2013, 19, 245–251. (IF: 0.875, Ranking in Applied Physics: 114/143)

C. K. Su, and Y. C. Sun*, Chemically Differentiating Ascorbate-Mediated Dissolution of Quantum Dots in Cell Culture Media, Nanoscale 2013, 5, 2073–2079. (IF: 7.394, Ranking in Nanoscience & Nanotechnology: 10/79)

H. Y. Liu*, J. H. Chao, C. Y Chuang, H. L. Chiu, C. W. Yang, and Y. C. Sun, Study of P, Ca, Sr, Ba and Pb Levels in Enamel and Dentine of Human Third Molars for Environmental and Archaeological Research, Advances in Anthropology 2013, 3, 71–77.

   2012

T. H. Wang, H. A. Hsieh, Y. K. Hsieh, C. S. Chiang, Y. C. Sun, and C. F. Wang*, The in Vivo Biodistribution and Fate of CdSe Quantum Dots in the Murine Model: a Laser Ablation Inductively Coupled Plasma Mass Spectrometry Study, Anal. Bioanal. Chem. 2012, 400, 3025–3036.(IF: 3.436, Ranking in Analytical Chemistry: 13/74)

C. K. Su, T. W. Lee, and Y. C. Sun*, Online Solid Phase Extraction Using a PVC-Packed Minicolumn Coupled with ICP-MS for Determination of Trace Multielements in Complicated Matrices, J. Anal. At. Spectrom. 2012, 27, 1585–1590. (IF: 3.466, Ranking in Analytical Chemistry: 12/74)

C. K. Su, Y. L. Lin, and Y. C. Sun*, Simultaneous in Vivo Monitoring of Multiple Brain Metals Using an Online Microdialysis-in-Loop Solid Phase Extraction-Inductively Coupled Plasma Mass Spectrometry System, J. Anal. At. Spectrom. 2012, 27, 56–62. (IF: 3.466, Ranking in Analytical Chemistry: 12/74)

   2011

T. T. Shih, W. Y. Tseng, K. H. Tsai, W. Y. Chen, M. W. Tsai, and Y. C. Sun*, Online Coupling of Ultraviolet Titanium Dioxide Film Reactor with Poly(Methyl Methacrylate) Solid Phase Extraction-Inductively Coupled Plasma Mass Spectrometry for Speciation of Trace Heavy Metals in Freshwater, Microchem. J. 2011, 99, 260–266. (IF: 2.746, Ranking in Analytical Chemistry: 20/74)

I. H. Hsu, T. C. Hsu, and Y. C. Sun*, Gold-Nanoparticle-Based Graphite Furnace Atomic Absorption Spectrometry Amplification and Magnetic Separation Method for Sensitive Detection of Mercuric Ions, Biosens. Bioelectron. 2011, 11, 4605–4609. (IF: 6.409, Ranking in Analytical Chemistry: 3/74)

I. H. Hsu, W. H. Chen, T. K. Wu, and Y. C. Sun*, Gold Nanoparticle-Based Inductively Coupled Plasma Mass Spectrometry Amplification and Magnetic Separation for the Sensitive Detection of a Virus-Specific RNA Sequence, J. Chromatogr. A 2011, 1218, 1795–1801. (IF: 4.169, Ranking in Analytical Chemistry: 6/74)

   2010

C. K. Su, C. W. Huang, C. S. Yang, Y. J. Wang, and Y. C. Sun*, In Vivo Monitoring of Quantum Dots in the Extracellular Space Using Push-Pull Perfusion Sampling, Online In-Tube Solid Phase Extraction, and Inductively Coupled Plasma Mass Spectrometry, Anal. Chem. 2010, 82, 7096–7102. (IF: 5.636, Ranking in Analytical Chemistry: 4/74)

C. K. Su, Y. C. Sun*, S. F. Tzeng, C. S. Yang, C. Y. Wang, and M. H. Yang, In Vivo Monitoring of the Transfer Kinetics of Trace Elements in Animal Brains with Hyphenated Inductively Coupled Plasma Mass Spectrometry Techniques, Mass Spectrom. Rev. 2010, 259, 392–424. (IF: 7.709, Ranking in Spectroscopy: 2/44)

P. L. Lee, Y. K. Chiu, Y. C. Sun, and Y. C. Ling*, Synthesis of a Hybrid Material Consisting of Magnetic Iron-Oxide Nanoparticles and Carbon Nanotubes as a Gas Adsorbent, Carbon 2010, 48, 1397–1404. (IF: 6.196, Ranking in Materials Science, Multidisciplinary: 26/259)

I. L. Chang, I. H. Hsu, M. H. Yang, and Y. C. Sun*, Coupling of an Electrodialyzer with Inductively Coupled Plasma Mass Spectrometry for the on-Line Determination of Trace Impurities in Silicon Wafers after Surface Metal Extraction, J. Chromatogr. A 2010, 1217, 1362–1367. (IF: 4.169, Ranking in Analytical Chemistry: 6/74)

C. K. Yang,  P. H. Chi, Y. C. Lin, M. H. Yang, and Y. C. Sun*, Development of an on-Line Isotope Dilution Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) Method for Determination of Boron in Silicon Wafers, Talanta 2010, 80, 1222–1227. (IF: 3.545, Ranking in Analytical Chemistry: 11/74)

   2009

K. J. Chen, I. H. Hsu, and Y. C. Sun*, Determination of Methylmercury and Inorganic Mercury by Coupling Short-Column Ion Chromatographic Separation, On-Line Photocatalyst-Assisted Vapor Generation, and Inductively Coupled Plasma Mass Spectrometry, J. Chromatogr. A2009, 1216, 8933–8938. (IF: 4.169, Ranking in Analytical Chemistry: 6/74)

P. L. Lee, Y. C. Sun, and Y. C. Ling*, Magnetic Nano-Adsorbent Integrated with Lab-on-Valve System for Trace Analysis of Multiple Heavy Metals, J. Anal. At. Spectrom. 2009, 24, 320–327. (IF: 3.466, Ranking in Analytical Chemistry: 12/74)

J. H. Chao*, M. T. Liu, S. A. Yeh, S. S. Huang, J. M. Wu, Y. L. Chang, F. Y. Hsu, C. Y. Chuang, H. Y. Liu, and Y. C. Sun, Using Medical Accelerators and Photon Activation to Determine Sr/Ca Concentration Ratios in Teeth, Appl. Radiat. Isotopes 2009, 67, 1121–1126. (IF: 1.231, Ranking in Nuclear Science & Technology: 8/34)

C. Y. Li, C. S. Chiang, M. L. Tsai, R. S. Hseu, W. Y. Shu, C. Y. Chuang, Y. C. Sun, Y. S. Chang, J. G. Lin, C. S. Chen, C. L. Huang, and I. C. Hsu*, Two-Sided Effect of Cordyceps Sinensis on Dendritic Cells in Different Physiological Stages, J. Leukoc. Biol. 2009, 85, 987–995. (IF: 4.289, Ranking in Cell Biology: 66/184)

   2008

C. K. Su, T. W. Li, and Y. C. Sun*, Online In-Tube Solid-Phase Extraction Using a Nonfunctionalized PVC Tube Coupled with ICPMS for in Vivo Monitoring of Trace Metals in Rat Brain Microdialysates,  Anal. Chem. 2008, 80, 6959–6967. (IF: 5.636, Ranking in Analytical Chemistry: 4/74)

Y. W. Lu, and Y. C. Sun*, An On-Line Electrodialyzer–ICP-MS Analytical System for Direct Determination of Trace Metal Impurities in KOH, J. Anal. At. Spectrom. 2008, 23, 574–578. (IF: 3.466, Ranking in Analytical Chemistry: 12/74)

M. W. Tsai, and Y. C. Sun*, On-Line Coupling of a Post-Column UV/TiO2 Film Reactor with an LC-HG-ICP-MS System for Continuous Determination of Dynamic Variation of Hydride- and Nonhydride-Forming Arsenic Species in Very Small Microdialysate Samples, Rapid Commun. Mass Spectrom. 2008, 86, 140–145. (IF: 2.253, Ranking in Analytical Chemistry: 30/74)

R. A. Doong*, S. H. Lee, C. C. Lee, Y. C. Sun, and S. C. Wu, Characterization and Composition of Heavy Metals and Persistent Organic Pollutants in Water and Estuarine Sediments from Gao-Ping River, Taiwan, Mar. Pollut. Bull. 2008, 57, 846–857. (IF: 2.991, Ranking in Environmental Sciences: 53/221)

　

　

   2007

Y. T. Chung, Y. C. Ling, C. S. Yang, Y. C. Sun*, P. L. Lee, C. Y. Lin, C. C. Hong, and M. H. Yang, In Vivo Monitoring of Multiple Trace Metals in the Brain Extracellular Fluid of Anesthetized Rats by Microdialysis-Membrane Desalter-ICPMS, Anal. Chem. 2007, 79, 8900–8910. (IF: 5.636, Ranking in Analytical Chemistry: 4/74)

M. L. Chang,* Y. C. Sun, R. A. Doong, S, C. Wu, and C. T. Fu, Concentrations and Correlations of Trace Metals in Estuarine Sediments- Interpretation by Multivariates Statistical Analysis and Elemental Normalization, J. Environ. Eng. Manage. 2007, 17, 143–150. (IF: 1.258, Ranking in Environmental Sciences: 128/216)

Y. C. Sun*, Y. J. Chen, and Y. N. Tsai, Determination of Urinary Arsenic Species Using an On-Line Nano-TiO2 Photooxidation Device Coupled with Microbore LC and Hydride Generation-ICP-MS System, Microchem. J. 2007, 86, 140–145. (IF: 2.746, Ranking in Analytical Chemistry: 20/74)

Y. C. Sun*, Yi-Wen. Lu, and Y. T. Chung, Online In-Tube Solid Phase Extraction Coupled to ICP-MS for In Vivo Determination of the Transfer Kinetics of Trace Elements in the Brain Extracellular Fluid of Anesthetized Rats, J. Anal. At. Spectrom. 2007, 22, 77–83. (IF: 3.466, Ranking in Analytical Chemistry: 12/74)

    2006

Y. C. Sun*, Y. C. Chang, and C. K. Su, On-Line HPLC-UV/Nano-TiO2-ICPMS System for the Determination of Inorganic Selenium Species, Anal. Chem. 2006, 78, 2640–2645. (IF: 5.636, Ranking in Analytical Chemistry: 4/74)