Cobalt Mediated Radical Polymerization (CMRP) is one of the most
efficient reversible-deactivation radical polymerization (RDRP)
technique to mediate the polymerization of vinyl acetate (VAc). We
studied
CMRP with various complexes, such as Co(TMP),
Co(Salen*),
Co(BpyBph)
as
well as
Co(FI)
kinetically
and thermal dynamically. We also developed a methdology of the
hybridization
of CMRP and atom transfer
radical
polymerization (ATRP)
to prepare various types of PVAc-based block copolymers.
Ring opening polymerization (ROP) is an impotant technique to prepare
biocompatible and biodegradable polyesters with precise aand narrowly
distributed molecular weight. Our group focus on the development of new
aluminum complexes for ROP. We are also finding the stratgy to
synthesize
block copolymers of cyclicesters and vinyl monomers.
Cancer therapy based on synergy effect, which is usually achieved by a
treatment of multiple drugs to patients, have recently gained a lot of
attenetion. A nano-vehicle with the capability of carrying mutiple
drugs
is able to improve drug-dosing efficiency. Our group focused on
developing
multi-drug nano-carriers with block copolymers. By tuning
the molecular structure of the block copolymer, we are able to
design
a carrier with desired properties.