俞鐘山 Chung-Shan Yu
Early diagnosis of cancer is the best way to beat cancer. Through the use of PET (positron emission tomography) and SPECT (single-photon emission computed tomography), cancer-targeted radiolabeled molecules can be monitored by non-invasive imaging for diagnosis. In order to develop cancer-targeted radiolabeled molecules efficiently, rapid parallel synthesis of solution-phase derived libraries followed by their in situ cell-based screening is an innovative approach. The core structures constitute natural product-like and drug-like molecules, e.g. nucleoside, glycoside, glycosphingolipid, ceramide, ethacrynic amide, fenbufen amide, glutathione and cyclic peptide. Molecules tagged with ultrahigh sensitive radionuclides e.g. fluorine-18 and iodine-123 have been intensively studied in this laboratory. Liver multidrug-resistant enzyme and cyclooxygenase might be targeted as a biomarker for cancer therapy using our newly developed 18F- and 123I- labeled new compounds. The data of pharmacokinetics will be useful for preclinical as well as clinical studies in the future.
1.Huang, H.-L.; Chiang, L.-W.; Chen, J.-R.; Huang, C.-W.; Yang, W.-K.; Chiang, C.-S.; Jeng, K.-C.; Lin, W.-Z.; Fan, S.-S.; Chen, J.-Z.; Yu, C.-S.* "Study of [18F]FLT and [123I]IaraU for cellular imaging in HSV1 tk-transfected murine fibrosarcoma cells: Evaluation of the tracer uptake using 5-fluoro, 5-iodo and 5-iodovinyl arabinosyl uridines as competitive probes", Nucl. Med. Biol. In press, 2011, xx-xx.
2.Su, Y.-H.; Chiang, L.-W.; Jeng, K.-C.; Huang, H.-L.; Chen, J.-Z.; Lin, W.-Z.; Huang, C.-W.; Yu, C.-S.*, "Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries", Bioorg. Med. Chem. Lett. 2011, 21, 1320-1324.
3.Lin, K.-I.; Yang, C.-H.; Huang, C.-W.; Jian, J.-Y.; Huang, Y.-C.*; Yu, C.-S.*, "Synthesis and structure-activity relationships of fenbufen amide analogs", Molecules 2010, 15, 8796-8803.
4.Chiang, L.-W.; Pei, K.; Chen, S.-W.; Huang, H.-L.; Lin, K.-J.; Yen, T.-C.; Yu, C.-S.*, "Combining a solution-phase derived library with in-situ cellular bioassay: Prompt screening of amide-forming minilibraries using MTT assay", Chem. Pharm. Bull. 2009, 57, 714-718.
5.Yu, C.-S.*; Wang, R.-T.; Chiang, L.-W.; Lee, M.-S., "Synthesis of 4',4'-C-diaminomethyl nucleoside derivative as a building block for constructing libraries via amide bond formation.", Tetrahedron Lett. 2007, 48, 2979-2982.
6.Yu, C.-S.*; Wang, H.-Y.; Chiang L.-W.; Pei, K., "Synthesis of rhamnosyl trisaccharide repeating unit to mimic the antigen determinant of Pseudomonas syringae lipopolysaccharide.", Synthesis 2007, 1412-1420.
7.Yu, C.-S.*; Chiang, L.-W.; Wu, C.-H.; Hsu, Z.-K.; Lee, M.-H.; Pan, S.-D.; Pei, K., "Syntheses of 5-fluoro and (E)-5-(2-fluorovinyl) arabinosyl uridine analogues as potential probes for the HSV-1 thymidine kinase gene", Synthesis 2006, 3835-3840.
8.Yu, C.-S.*; Chiang, L.-W.; Wu, C.-H.; Wang, R.-T.; Chen, S.-W.; Wang, H.-Y.; Yeh, C.-H., "Synthesis of 5-radioiodoarbinosyl uridine analogs for Probing HSV TK gene: An unexpected chelating effect", Nucl. Med. Biol. 2006, 33, 367-370.
• 2008 – Present Associate Professor
Department of Biomedical Engineering
and Environmental Sciences, National
Tsing Hua University, Taiwan
• 2003 – 2008 Assistant Professor
Department of Nuclear Science,
National Tsing Hua University, Taiwan
• 1999 – 2003 Post-doctoral Fellowship
Department of Chemistry, Academia
• 1995 – 1999 PhD in Organic Chemistry
Department of Chemistry, Heidelberg
• 1994 – 1995 MS in Organic Chemistry
Department of Chemistry, Heidelberg
• 1993 – 1994 Reaserch Assistant
PET/Cyclotron Center, Taipei Veterans
General Hospital, Taiwan
• 1989 – 1991 MS in Radiochemistry
Department of Chemistry, National Tsing
Hua University, Taiwan
• 1985 – 1989 Bachelor in Chemistry
Department of Chemistry, Tamkang
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