老師個人履歷
教學研究重點
專利
實驗室成員
實驗室設備
照片集
E-mail
清華大學
生醫工程與
環境科學系
俞老師實驗室
607室
新竹市光復路
二段101號
NS607, Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University 101, Sec. 2 Kuang-Fu Road, Hsinchu, Taiwan 300
老師與實驗室的計畫&成果
發表論文
2014
Supporting information
2013
Ho-Lien Huang , Chun-Nan Yeh ,Wei-Yuan Lee , Ying-Cheng Huang , Kang-Wei Chang , Kun-Ju Lin ,Shu-Fan Tien, Wen-Chin Su , Ching-Hsiuan Yang , Jenn-Tzong Chen , Wuu-Jyh Lin , Shio-Shio Fan,Chung-Shan Yu "[123I]Iodooctyl fenbufen amide as a SPECT tracer for imaging tumors that over-express COX enzymes" Biomaterials (2013), http://dx.doi.org/10.1016/j.biomaterials.2013.01.050
2012
Ho-Lien Huang, Chun-Nan Yeh, Kang-Wei Chang, Jezon Chen, Kun-Ju Lin, Li-Wu Chiang, Kee-Ching Jeng, Wei-Ting Wang, Ken-Hong Lim, Caleb Gonshen Chen, Kun-I Lin, Ying-Cheng Huang, Wuu-Jyh Lin, Tzu-Chen Yen and Chung-Shan Yu﹡“Synthesis and Evaluation of [18F]Fluorobutyl Ethacrynic Amide: A Potential PET Tracer for Studying Glutathione Transferase＂Bioorg. Med. Chem. Lett. (SCI)
Yin-Cheng Huang, Li-Wu Chiang, Kai-Shiang Chang, Wen-Chin Su, Yi-Hsian Lin, Kee-Ching Jeng, Kun-I Lin, Kuo-Yen Liao, Ho-Lein Huang and Chung-Shan Yu* “Synthesis of Amino Core Compounds of Galactosyl Phytosyl Ceramide Analogs for Developing iNKT-Cell Inducers＂Molecules, 2012, 17, 3058-3081.(SCI)
Ho-Lien Huang, Li-Wu Chiang, Jia-Rong Chen, Wen K. Yang, Kee-Ching Jeng, Jenn-Tzong Chen, Ting-Shien Duh, Wuu-Jyh Lin, Shiou-Shiow Farn, Chi-Shiun Chiang, Chia-WenHuang, Kun-I Lin1, and Chung-Shan Yu* “Study of [18F]FLT and [123I]IaraU for cellular imaging in HSV1 tk-transfected murine fibrosarcoma cells: Evaluation of the tracer uptake using 5-fluoro, 5-iodoand 5-iodovinyl arabinosyl uridines as competitive probes” Nucl. Med. Biol. 2012, 39, 371-376(SCI). (國科會計劃98-2113-M-007-012 and NL0991036).
2011
Yuan-Hsiao Su, Li-Wu Chiang, Kee-Ching Jeng, Ho-Lien Huang, Jenn-Tzong Chen, Wuu-Jyh Lin, Chia-Wen Huang and Chung-Shan Yu*“Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries”Bioorg. Med. Chem. Lett. 2011, 21, 1320-1324. (SCI)
2010
Kun-I Lin, Chao-Hsun Yang, Chia-Wen Huang, Jhen-Yi Jian, Yu-Chun Huang and Chung-Shan Yu* “Synthesis and Structure-Activity Relationships of Fenbufen Amide Analogs”Molecules, 2010, 15, 8796-8803. (SCI)
2009
Li-Wu Chiang, Si-Der Pan, Jem-Mau Lo, Chung-Shan Yu*“Triflic Acid-Promoted Formylation of Ceramide in Dimethylformamide”Chin. J. Chem. 2009, 27, 2296-2299.
Li-Wu Chiang, Kai Pei, Shao-Wei Chen, Ho-Lien Huang, Kun-Ju Lin, Tzu-Chen Yen, and Chung-Shan Yu* “Combining a solution-phase derived library with in-situ cellular bioassay: Prompt screening of amide-forming minilibraries using MTT assay”Chem. Pharm. Bullet. 2009, 57, 714-718. (SCI)
2007
Jem-Mau Lo, Li-Wu Chiang, Shao-Wei Chen, Zhi-Wei Fu, Kai Pei, Chung-Shan Yu* “Recent advances in solution-phase derived synthetic libraries and rapid bioassays on microtiter plates” Invited review paper for publication in Chim. Oggi. 2007, 25, 46-50. (SCI) (國科會計劃NSC 95-2113-M-007-039)
Chi-Shiun Chiang, Ching-Fang You, Li-Wu Chiang, Shao-Wei Chen, Jem-Mau Lo, Chung-Shan Yu*“Comparison of bioactivities of 5-fluoro, 5-iodo, 5-iodovinyl, and 5-fluorovinyl arabinosyl uridines against SR-39 TK-transfected murine prostate cancer cells” Chem. Pharm. Bullet. Accept. (SCI) (國科會計劃 NSC-96-2113-M-007-028-MY2)
Chien-Hung Yeh, Si-Der Pan, Shao-Wei Chen, Zhi-Wei Fu, Li-Wu Chiang, Chung-Shan Yu* “An improved method for synthesis of ceramide for constructing a-galactosyl ceramide analogs.” J. Chin. Chem. Soc. Taipei. accepted. (SCI) (國科會計劃 NSC 95-2113-M-007-039)
Chung-Shan Yu*, Ren-Tsong Wang, Li-Wu Chiang, Ming-Shun Lee “Synthesis of 4',4'-C-diaminomethyl nucleoside derivative as a building block for constructing libraries via amide bond formation.” Tetrahedron Lett., 2007 Accept. (SCI) (國科會計劃 NSC 94-2113-M-007-005)
Chung-Shan Yu*, Heng-Yen Wang and Li-Wu Chiang and Kai Pei“Synthesis of rhamnosyl trisaccharide repeating unit to mimic the antigen determinant of Pseudomonas syringae lipopolysaccharide.” Synthesis, 2007 Accept. (SCI) (國科會計劃 NSC 94-2113-M-007-005)
Kun-I Lin, Li-Wu Chiang, Chien-Hung Wu, Shao-Wei Chen, Chung-Shan Yu* “Synthesis of 5-radioiodoarabinosyl uridine analog for probing HSV-1 thymidine kinase gene.” Accepted. J. Chin. Chem. Soc. Taipei. 2007, xx-xx. (in press) (SCI) (國科會計劃 NSC 94-2113-M-007-005)
2006
Chung-Shan Yu*, Chien-Hung Wu, Li-Wu Chiang, Kai Pei and Zhi-Kai Hsu, “Synthesis of (E)-5-(2-fluorovinyl)arabinosyl uridine analog as a potential probe for HSV-1 thymidine kinase gene” Synthesis, 2006, 3835-3840 (SCI). (國科會計劃 NSC 94-2113-M-007-005).
Li-Wu Chiang, Jem-Miao Lo, Chung-Shan Yu*, “Synthesis of Rradiolabeled Nucleoside Analogs for Probing Cancer Gene Therapy” Chemistry (The Chem. Soc., Taipei), 2006, 64, 179-190 (Review Article in Chinese)
Chung-Shan Yu*, Li-Wu Chiang, Chien-Hung Wu, Ren-Tsong Wang, Shao-Wei Chen, Heng-Yen Wang, and Chien-Hung Yeh, “Synthesis of 5-radioiodoarbinosyl uridine analogs for Probing HSV TK gene: An unexpected chelating effect” Nucl. Med. Biol. 2006, 33, 367-370 (SCI). (國科會計劃 93-2113-M-007-038).
2005
Chung-Shan Yu*, Chien-Hung Wu, Li-Wu Chiang, Ren-Tsong Wang, Heng-Yen Wang, Chien-Hung Yeh, and Kun-I Lin, “Synthesis of (E)-5-(2-radioiodovinyl)arabinosyl Uridine Analog for Probing HSV-1 Thymidine Kinase Gene” Chemistry Letters 2005, 34 (10), 1390-1391 (SCI). (國科會計劃 NSC 93-2113-M-007-038).
2003
Yu, C.-S.*; Oberdorfer, F. “Synthesis of a Novel Aldehyde: 4-O-methyl-5-formylmethyl-2’-deoxyuridine Derivatives” Nucleosides,Nucleotides Nucleic Acids 2003, 22 (1), 71-84.
Yu, C.-S.*; Zeisler, S.; Eisenbarth, J.; Weber, K.; Runz, A.; Oberdorfer, F.“Synthesis of 5-(2-radiohaloethyl)- and 5-(2-radiohalovinyl)-2’-deoxyuridines.Novel Types of Radiotracer for Monitoring Cancer Gene Therapy with PET” J.Labelled Compd. Radiopharm. 2003, 46, 1-19.12.
2001
Yu, C.-S.; Niikura, K.; Lin, C.-C.*; Wong, C.-H*. “The Thioglycoside and Glycosyl Phosphite of 5-Azido Sialic Acid: Excellent Donors for the a-Glycosylation of Primary Hydroxy Groups” Angewandte Chemie 2001, 40, 86-88.
2000
C.-S Yu, F. Oberdorfer* “Synthesis of (E)-5-[2-(tri-n-butylstannyl)vinyl]substituted 2’-deoxyuridine derivatives for use in halogenation and radiohalogenation reactions” Synlett 2000, 86-88.
1999
C.-S Yu, F. Oberdorfer* “Synthesis of (E)-5-[2-(tri-n-butylstannyl)vinyl] substituted 2’-deoxyuridine derivatives for use in halogenation and radiohalogenation reactions” Synlett 2000, 86-88.14. C.-S. Yu, F. Oberdorfer* “Synthesis of 4-O-methyl-protected 5-(2-hydroxyethy)-2’-deoxyuridine derivatives and their nucleophilic fluorination to 5-(2-fluoroethyl)-2’-deoxyuridine” Synthesis 1999, 2057-2064.
