We develope multifunctional nano-scale drug delivery plateforms for chemotherapy, gene therapy, immunotherapy and diagnostic imaging.

We design cutting edge gene therapy strategies to treat maliganat diseases.

We explore the mechanistic underpinnings for the development of resistance to cancer therapy and synthesize new drugs to overcome the limitation of current treatments.

We’re trying to go from impossible to possible in principle, to practical and usable by real people, and finally to devices that are affordable. 

—Seth Teller

Our Team

We are actively recruiting Undergraduate and Graduate students to join us!

Yunching (Becky) Chen

Principal investigator

宋雲傑

Graduate student

黃冠瑋

Research Assistance

施昱全

Graduate student

金珮如

Graduate student

黃璽倩

Graduate student

李易安

Graduate student

楊昇

Graduate student

穆宣佑

Graduate student

黃睿麟

Graduate student

Ta Ngoc Yen Nhi (Sammy)

Graduate student

Dinh Kieu Trinh (Tracy)

Graduate student

鄭聖良

Graduate student

廖育暉

Graduate student

謝心慈

Summer student

余燕寧

Summer student
To translate the innovative diagnostic and therapeutic strategies from bench to bedside.

Drug Targeting Lab

News

Thou crownest the year with thy goodness; and thy paths drop fatness.

Nov 2019: Congratulations! New paper (by宋雲傑) accepted on Nature Nanotechnology
Nov 2019:Congratulations! New paper (by 黃冠瑋) accepted on Science Advances
May 2018: Congratulations! 宋雲傑/張智鈞/黃冠瑋got 2018 CRS YS travel grant award!
June 2018: Congratulations! 黃璽倩/金珮如榮獲科技部大專學生研究計畫創作獎
Sep 2017: Congratulations! New paper (by Chun-Hung Liu & Guann-Gen Chern) accepted on Hepatology
Aug 2017: Congratulations! Kuan-Wei Huang got 2017 ISOMRM Excellent Poster Award!
July 2017: Congratulations! We graduated! 可以看出哪幾隻是畢業生嗎?
July 2017:  2017 "Cancer Nanotechnology" Gordon Research Conference in Vermon, USA
July 2017: at Boston,USA 然而龍蝦是波城沒有之一
June 2017: Congratulations! Guann-Gen Chern got ICBP 2017 Excellent Poster Award!
June 2017: The final lecture of our course "Daily Biomedical Engineering" - 10520BME 200100
June 2017: Congratulations! Po-Han Chao got 2017Best Thesis Award of Engineering School NTHU!
June 2017: Congratulations! Dr. Yunching (Becky) Chen got Outstanding Young Investigator Award of Engineering School NTHU
June 2017: Congratulations! Hsi-Chien Huang and Peiru Jin got MOST undergraduate student research grant!
Aug 2016: Congratulations! Chih-Chun Chang got 2017Best Thesis Award of Engineering School NTHU!
Feb 2017: Congratulations! New paper (by Ya-Chi Liu & Yun-Chieh Sung) accepted on Scientific Report!
Success belongs to those who focus on the right things and persist.

Drug Targeting Lab

Publications

1. Yun-Chieh Sung, Pei-Ru Jin, Li-An Chu, Fu-Fei Hsu, Mei-Ren Wang, Chih-Chun Chang, Show-Jen Chiou, Jiantai Timothy Qiu, Dong-Yu Gao, Chu-Chi Lin, Yu-Sing Chen, Yi-Chiung Hsu, Jane Wang, Fu-Nien Wang, Pei-Lun Yu, Ann-Shyn Chiang,  Anthony Yan-Tang Wu, John Jun-Sheng Ko, Charles Pin-Kuang Lai, Tsai-Te Lu*, Yunching Chen* (2019). Delivery of Nitric Oxide with a Nanocarrier Promotes Tumour Vessel Normalization and Potentiates Anti-Cancer Therapies. Nature Nanotechnology. (in press)

2. Kuan-Wei Huang, Fu-Fei Hsu, Jiantai Timothy Qiu, Guann-Jen Chern, Yi-An Lee, Chih-Chun Chang1, Yu-Ting Huang, Yun-Chieh Sung, Cheng-Chin Chiang, Rui-Lin Huang, Chu-Chi Lin, Trinh Kieu Dinh, Hsi-Chien Huang, Yu-Chuan Shih, Donia Alson, Chun-Yen Lin, Yung-Chang Lin, Po-Chiao Chang, Shu-Yi Lin*, Yunching Chen* (2019). Highly Efficient and Tumor-Selective Nanoparticles for Dual-Targeted Immunogene Therapy against Cancer. Science Advances. (in press)

3. Cin‐Hao Lin, Hsin‐Chuan Wen, Cheng‐Chin Chiang, Jen‐Sheng Huang, Yunching Chen, Sheng‐Kai Wang* (2019). Polyproline Tri‐Helix Macrocycles as Nanosized Scaffolds to Control Ligand Patterns for Selective Protein Oligomer Interactions. Small. 15(20).

4. Hung-Hsun Lu, Cheng-Hung Huang, Ting-Yun Shiue, Fu-Sheng Wang, Ko-Kai Chang, Yunching Chen, Chi-How Peng* (2019). Highly Efficient Gene Release in Spatiotemporal Precision Approached by Light and pH Dual Responsive Copolymers. Chemical Science. 10, 284-292. (IF=9.0)

5. Kuan-Wei Huang, Yu-Tsung Lai, Guann-Jen Chern, Shao-Feng Huang, Chia-Lung Tsai, Yun-Chieh Sung, Cheng-Chin Chiang, Pi-Bei Hwang, Ting-Lun Ho, Rui-Lin Huang, Ting-Yun Shiue, Yunching Chen*, and Sheng-Kai Wang* (2018). Galactose Derivative-Modified Nanoparticles for Efficient siRNA Delivery to Hepatocellular Carcinoma. Biomacromolecules. 19 (6), 2330–2339. (IF=5.8

6. Chih-Chun Chang, Yang Yang, Dong-Yu Gao, Hui-Teng Cheng, Bryan Hoang, Po-Han Chao, Ling-Hsuan Chen, Joseph Bteich, Tsaiyu Chiang, Jia-Yu Liu, Shyh-Dar Li*, Yunching Chen* (2018). Docetaxel-carboxymethylcellulose nanoparticles ameliorate CCl4-induced hepatic fibrosis in Mice. Journal of Drug Targeting. 27:1-9. (IF=3.4)

7. Yun-Chieh Sung, Ya-Chi Liu, Po-Han Chao, Chih-Chun Chang, Ts-Ting Lin, Ja-An Lin, Hui-Teng Cheng, Jane Wang, Charles P. Lai, Ling-Hsuan Chen, Peiru Jin, Anthony Y. Wu, Tsaiyu Chiang, Dong-Yu Gao, Dan G. Duda, Yunching Chen* (2018) Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development. Theranostics. 8(4):894-905. (IF=8.8)

8. Chun-Hung Liu, Guann-Gen Chern, Fu-Fei Hsu, Kuan-Wei Huang, Yun-Chieh Sung, Hsi-Chien Huang, Jiantai Timothy Qiu, Chu-Chi Lin, Chien-Hsun Wu, Han-Chung Wu, Jia-Yu Liu, Yunching Chen* (2018) A multifunctional nanocarrier for efficient TRAIL-based gene therapy against hepatocellular carcinoma with desmoplasia. Hepatology. 67(3):899-913. (4%, IF=13)

9. Yunching Chen*#, Ya-Chi Liu#, Yun-Chieh Sung#, Rakesh R. Ramjiawan, Ts-Ting Lin, Chih-Chun Chang, Kuo-Shyang Jeng, Chiung-Fang Chang, Chun-Hung Liu, Dong-Yu Gao, Fu-Fei Hsu, Annique M. Duyverman, Shuji Kitahara, Peigen Huang, Simona Dima, Irinel Popescu, Keith T. Flaherty, Andrew X. Zhu, Nabeel Bardeesy, Rakesh K. Jain, Cyril H. Benes, and Dan G. Duda* (2017) Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors. Sci Rep. 7, 44123. (IF=5.2)

10. Liying Wang, Yunching Chen, Hsin Yao Lin, Yung-Te Hou, Ling-Chu Yang, Aileen Y. Sun, Jia-Yu Liu, Chien-Wen Chang, and Dehui Wan (2017) Near-IR-Absorbing Gold Nanoframes with Enhanced Physiological Stability and Improved Biocompatibility for In Vivo Biomedical Applications. ACS Appl. Mater. Interfaces. 9 (4), 3873–3884. (IF=7.1)

11. Ts-Ting Lin#, Dong-Yu Gao#, Ya-Chi Liu, Yun-Chieh Sung, Dehui Wan, Jia-Yu Liu, Tsaiyu Chiang, Liying Wang, Yunching Chen* (2016) Development and Characterization of Sorafenib-Loaded PLGA Nanoparticles for the Systemic Treatment of Liver Fibrosis. Journal of Controlled Release. 10, 211:62~70. (4%, IF=7.7)  

12. Chun-Hung Liu#, Kun-Ming Chan#, Tsaiyu Chiang#, Jia-Yu Liu, Guann-Gen Chern, Fu-Fei Hsu, Yu-Hsuan Wu, Ya-Chi Liu, Yunching Chen*(2016) Dual-functional nanoparticles targeting CXCR4 and delivering anti-angiogenic siRNA ameliorate liver fibrosis. Molecular Pharmaceutics. 13 (7), 2253–2262. (11%, IF=4.4)

13. Chun-Jui Lin, Chen-Hsiang Kuan, Hsi-Chin Wu, Yunching Chen, Chien-Wen Chang, Jih-Yang Huang, Tzu-Wei Wang (2016) Dual Responsive Self-assembling Nanocarrier with Active Targeting Peptide Ligand for Orthotopic Ovarian Cancer Theranostics. Biomaterials. 90:12-26.  (2%, IF=8.6)

14. Jia-Yu Liu, Tsaiyu Chiang, Chun-Hung Liu, Guann-Gen Chern, Ts-Ting Lin, Dong-Yu Gao, Yunching Chen* (2015) Delivery of siRNA using CXCR4-Targeted Nanoparticles Modulates Tumor Microenvironment and Achieves a Potent Anti-Tumor Response in Liver Cancer. Molecular Therapy. 23(11):1772-82.

15. Dong-Yu Gao, Ts-Ting Lin, Yun-Chieh Sung, Ya Chi Liu, Wen-Hsuan Chiang, Chih-Chun Chang, Jia-Yu Liu, Yunching Chen* (2015) CXCR4-Targeted Lipid-Coated PLGA Nanoparticles Deliver Sorafenib and Overcome Acquired Drug Resistance in Liver Cancer. Biomaterials. 67: 194~203.

16. Yunching Chen* & Dan G. Duda* (2015) Targeting immunosuppression after standard sorafenib treatment to facilitate immune checkpoint blockade in hepatocellular carcinoma – an auto-commentary on clinical potential and future development. Oncoimmunology. 27;4(10).

17. Thomas Reiberger, Yunching Chen, Rakesh R. Ramjiawan, Tai Hato, Christopher Fan, Rekha Samuel, Sylvie Roberge, Peigen Huang, Gregory Y. Lauwers, Andrew X. Zhu, Nabeel Bardeesy, Rakesh K. Jain, Dan G. Duda (2015). An orthotopic mouse model of hepatocellular carcinoma with underlying liver cirrhosis. Nature Protocol. 10: 1264–1274.

18. Yunching Chen, Rakesh R. Ramjiawan, Thomas Reiberger, Mei Rosa Ng, Tai Hato, Yuhui Huang, Hiroki Ochiai, Elizabeth C. Unan, Teja P. Reddy, Peigen Huang, Andrew X. Zhu, Rakesh K. Jain, Dan G. Duda* (2015). CXCR4 inhibition in tumor microenvironment facilitates anti-PD-1 immunotherapy in sorafenib-treated HCC in mice. Hepatology, 61(5):1591-602. (SCI, 3/75).

19. Hee-Sun Hana, Elisabeth Niemeyerb, Yuhui Huangb, Walid S. Kamounb, John D. Martinb,c, Jayeeta Bhaumikb, Yunching Chen, Sylvie Robergeb, Jian Cuia, Margaret R. Martinb, Dai Fukumurab, Rakesh K. Jainb,1, 69 Moungi G. Bawendib,1, and Dan G. Dudab (2014). Novel quantum dot/antibody conjugates for in vivo cytometric imaging in mice . Proceedings of the National Academy of Sciences, 112(5):1350-5.

20. Yunching Chen*, Dong-Yu Gao, Leaf Huang (2014). In Vivo Delivery of miRNAs For Cancer Therapy: Challenges and Strategies. Advanced Drug Delivery Reviews, 81:128–141. (SCI, 4/256, PHARMACOLOGY & PHARMACY).

21. Yunching Chen, Yuhui Huang, Thomas Reiberger, Annique M. Duyverman, Peigen Huang, Rekha Samue, Lotte Hiddingh, Sylvie Roberge, Christina Koppel, Gregory Y. Lauwers, Andrew X. Zhu, Rakesh K. Jain, Dan G. Duda* (2014). Differential effects of sorafenib on liver versus tumor fibrosis mediated by SDF1α/CXCR4 axis and Gr-1+ myeloid cell infiltration in mice. Hepatology, 59(4):1435-47. (SCI, 2/74).

22. Yunching Chen*, Surendar Reddy Bathula, Jun Li and Leaf Huang. Multi-functional nanoparticles delivering siRNA and doxorubicin overcome drug resistance in cancer. J Biol Chem, 2010. 285(29): p. 22639-50. impact factor: 4.8

23. Yunching Chen, Xiaodong Zhu, Xiaoju Zhang, Bin Liu and Leaf Huang. Nanoparticles modified with tumor-targeting scFv Deliver siRNA and miRNA for Cancer Therapy. Mol Ther, 2010. 18(9): p. 1650-6. impact factor: 7

24. Yunching Chen, Qi Yang, Surendar Reddy Bathula and Leaf Huang. Targeted nanoparticles deliver siRNA to melanoma. J Invest Dermatol, 2010. 130 (12): p.2790-8. impact factor: 6.2

25. Yunching Chen, Jinzi Wu and Leaf Huang. Nanoparticles Targeted with Tumor Homing peptide Motif Deliver c-Myc siRNA And Doxorubicin for Targeted Anticancer Therapy. Mol Ther, 2010. 18(4): p. 828-34. impact factor: 7

26. Yunching Chen, J.S., Qi Yang, Raffaella Fittipaldi, Surendar Reddy Bathula and Leaf Huang. Novel Cationic Lipid That Delivers and Enhances Therapeutic Activity of siRNA in Lung Cancer Cells. Mol Pharm, 2009. 6(3): p. 696-705. impact factor: 4.5

27. Jun Li; Yun-Ching Chen; Yu-Cheng Tseng; Leaf Huang, Biodegradable Calcium Phosphate Nanoparticle with Lipid Coating for Systemic siRNA Delivery. Journal of Controlled Release, 2010. 142(3): p. 416-21. impact factor: 7.6

28. Yunching Chen and Leaf Huang. Tumor-targeted delivery of siRNA by non-viral vector: safe and effective cancer therapy. Expert Opin Drug Deliv 5, (12), 1301-11.

29. Shyh-Dar Li, Yung-Ching Chen, Michael J. Hackett and Leaf Huang. Targeted Delivery of siRNA by Self-assembled Nanoparticles. Mol Ther 16 (1): 163-169, 2008. impact factor: 7

30. Chen, Y.C., Huang, H.N., Lin, C.T., Chen, Y.F., King, C.C., and Wu, H.C. (2007). Generation and characterization of monoclonal antibodies against dengue virus type 1 for epitope mapping and serological detection by epitope-based peptide antigens. Clin Vaccine Immunol 14, 404-411.

31. Liu, I.J., Chiu, C.Y., Chen, Y.C., Wu H.C. Molecular mimicry of human endothelial cell antigen by autoantibodies to nonstructural protein 1 of dengue virus. J Biol Chem, 2011. 18;286(11):9726-36.

32. Lin, D.Y., Huang, Y.S., Jeng, J.C., Kuo, H.Y., Chang, C.C., Chao, T.T., Ho, C.C., Chen, Y.C., Lin, T.P., Fang, H.I., et al. (2006). Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol Cell 24, 341-354.

33. Lu, K., Liang, C.L., Chen, H.J., Chen, S.D., Hsu, H.C., Chen, Y.C., Hsu, F.F., and Cho, C.L. (2003). Nuclear factor-kappaB-regulated cyclooxygenase-2 expression in surgery-associated paraspinal muscle injury in rats. J Neurosurg 98, 181-187.

34. Lu, K., Liang, C.L., Cho, C.L., Chen, H.J., Hsu, H.C., Yiin, S.J., Chern, C.L., Chen, Y.C., and Lee, T.C. (2002). Oxidative stress and heat shock protein response in human paraspinal muscles during retraction. J Neurosurg 97, 75-81.

 

 

Contact us

Dr. Yunching (Becky) Chen
Institute of Biomedical Engineering
Address: 101, Section 2, Kuang-Fu Road, Hsinchu, Taiwan 30013
TEL: +886 (3) 5715131 Ext 35513
Email: yunching@mx.nthu.edu.tw